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4-hydroxyestradiol

Known as: 4-Hydroxyestradiol-17beta, Estra-1,3,5(10)-Triene-3,14,17beta-Triol, 4-Hydroxy-17-Beta-Estradiol 
A metabolite formed during the metabolism of 17beta-estradiol by hydroxylation of the carbon at position 4 by cytochrome P450 1B1, with potential… Expand
National Institutes of Health

Papers overview

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Review
2006
Review
2006
Exposure to estrogens is associated with increased risk of breast and other types of human cancer. Estrogens are converted to… Expand
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Highly Cited
2001
Highly Cited
2001
Treatment of SENCAR mouse skin with dibenzo[a,l]pyrene results in abundant formation of abasic sites that undergo error-prone… Expand
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Highly Cited
2001
Highly Cited
2001
The oxidative metabolism of 17beta-estradiol (E2) and estrone (E1) to catechol estrogens (2-OHE2, 4-OHE2, 2-OHE1, and 4-OHE1) and… Expand
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Review
2000
Review
2000
Estrogens induce tumors in laboratory animals and have been associated with breast and uterine cancers in humans. In relation to… Expand
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Review
2000
Review
2000
The natural hormone 17 beta-estradiol (E2) induces tumors in various organs of rats, mice, and hamsters. In humans, slightly… Expand
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Highly Cited
1999
Highly Cited
1999
Catechol-O-methyltransferase (COMT, EC 2.1.1.6) is a ubiquitous enzyme that is crucial to the metabolism of carcinogenic… Expand
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Highly Cited
1997
Highly Cited
1997
The rat estrogen receptor (ER) exists as two subtypes, ER alpha and ER beta, which differ in the C-terminal ligand binding domain… Expand
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Highly Cited
1997
Highly Cited
1997
The rat estrogen receptor (ER) exists as two subtypes, ERα and ERβ, which differ in the C-terminal ligand binding domain and in… Expand
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Highly Cited
1997
Highly Cited
1997
Cancer is a disease that begins with mutation of critical genes: oncogenes and tumor suppressor genes. Our research on… Expand
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Highly Cited
1996
Highly Cited
1996
Estrogen is a known risk factor in human breast cancer. In rodent models, estradiol has been shown to induce tumors in those… Expand
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