4-hydroxyestradiol

Known as: 4-Hydroxyestradiol-17beta, Estra-1,3,5(10)-Triene-3,14,17beta-Triol, 4-Hydroxy-17-Beta-Estradiol 
A metabolite formed during the metabolism of 17beta-estradiol by hydroxylation of the carbon at position 4 by cytochrome P450 1B1, with potential… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1976-2018
05101519762018

Papers overview

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2006
2006
Estrogens are hypothesized to contribute to breast cancer via estrogen receptor-mediated increases in cell proliferation and via… (More)
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2006
2006
An elevated incidence of breast cancer in women has been associated with prolonged exposure to high levels of estrogens. Our… (More)
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2002
2002
Prostate carcinomas arise in 100% of Noble rats treated with estradiol and testosterone. We hypothesize that estrogens initiate… (More)
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Highly Cited
2000
Highly Cited
2000
Most drug metabolizing cytochrome P450s (P450) are predominantly expressed in the liver. In contrast, human CYP1B1 is an… (More)
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Highly Cited
1997
Highly Cited
1997
The rat estrogen receptor (ER) exists as two subtypes, ER alpha and ER beta, which differ in the C-terminal ligand binding domain… (More)
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Highly Cited
1997
Highly Cited
1997
The rat estrogen receptor (ER) exists as two subtypes, ERa and ERb, which differ in the C-terminal ligand binding domain and in… (More)
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Highly Cited
1997
Highly Cited
1997
Cancer is a disease that begins with mutation of critical genes: oncogenes and tumor suppressor genes. Our research on… (More)
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Highly Cited
1996
Highly Cited
1996
Estrogen is a known risk factor in human breast cancer. In rodent models, estradiol has been shown to induce tumors in those… (More)
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Highly Cited
1996
Highly Cited
1996
Until recently, steroid hormones were believed to act only on cells containing intracellular receptors. However, recent evidence… (More)
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1989
1989
The binding of catechol estrogens, epoxyenones and methoxyestrogens was evaluated using estrogen receptors in cytosol prepared… (More)
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