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4-hydroxyestradiol

Known as: 4-Hydroxyestradiol-17beta, Estra-1,3,5(10)-Triene-3,14,17beta-Triol, 4-Hydroxy-17-Beta-Estradiol 
A metabolite formed during the metabolism of 17beta-estradiol by hydroxylation of the carbon at position 4 by cytochrome P450 1B1, with potential… 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Estrogens, Catechol

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2000
Review
2000
Estrogens as endogenous genotoxic agents--DNA adducts and mutations.
Estrogens induce tumors in laboratory animals and have been associated with breast and uterine cancers in humans. In relation to… 
Highly Cited
2000
Highly Cited
2000
Antioxidant activities of estrogens against aqueous and lipophilic radicals; differences between phenol and catechol estrogens.
Highly Cited
1999
Highly Cited
1999
The Monkey and Human Uridine Diphosphate-Glucuronosyltransferase UGT1A9, Expressed in Steroid Target Tissues, Are Estrogen-Conjugating Enzymes.
Considering the physiologic importance of the steroid response, which is regulated in part by steroid levels in a given tissue… 
Highly Cited
1998
Highly Cited
1998
Synthesis and structure elucidation of estrogen quinones conjugated with cysteine, N-acetylcysteine, and glutathione.
Catechol estrogen quinones (CE-Q) have been implicated as ultimate carcinogenic metabolites in estrogen-induced carcinogenesis… 
Highly Cited
1996
Highly Cited
1996
Estradiol reduces calcium currents in rat neostriatal neurons via a membrane receptor
Until recently, steroid hormones were believed to act only on cells containing intracellular receptors. However, recent evidence… 
Highly Cited
1996
Highly Cited
1996
4-Hydroxylation of estrogens as marker of human mammary tumors.
Estrogen is a known risk factor in human breast cancer. In rodent models, estradiol has been shown to induce tumors in those… 
Highly Cited
1994
Highly Cited
1994
Steroid sulfation by expressed human cytosolic sulfotransferases
Review
1990
Review
1990
Genotoxic effects of estrogens.
  • J. Liehr
  • Mutation research
  • 1990
  • Corpus ID: 25712773
Highly Cited
1990
Highly Cited
1990
Cloning and expression of human liver UDP-glucuronosyltransferase in COS-1 cells. 3,4-catechol estrogens and estriol as primary substrates.
Highly Cited
1989
Highly Cited
1989
The cytotoxic effects of estradiol-17 beta, catecholestradiols and methoxyestradiols on dividing MCF-7 and HeLa cells.
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