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4-hydroxyestradiol

Known as: 4-Hydroxyestradiol-17beta, Estra-1,3,5(10)-Triene-3,14,17beta-Triol, 4-Hydroxy-17-Beta-Estradiol 
A metabolite formed during the metabolism of 17beta-estradiol by hydroxylation of the carbon at position 4 by cytochrome P450 1B1, with potential… 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Estrogens, Catechol

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
Expression and Estradiol Regulation of Wnt Genes in the Mouse Blastocyst Identify a Candidate Pathway for Embryo-Maternal Signaling at Implantation1
Abstract Implantation of mammalian embryos depends on differentiation of the blastocyst to a competent state and of the uterine… 
Highly Cited
2001
Highly Cited
2001
Characterization of the NADPH-dependent metabolism of 17beta-estradiol to multiple metabolites by human liver microsomes and selectively expressed human cytochrome P450 3A4 and 3A5.
We characterized the NADPH-dependent metabolism of 17beta-estradiol (E2) by liver microsomes from 21 male and 12 female human… 
Highly Cited
1998
Highly Cited
1998
Synergistic induction of DNA strand breakage by catechol-estrogen and nitric oxide: implications for hormonal carcinogenesis.
1998
1998
Metabolic activation and formation of DNA adducts of hexestrol, a synthetic nonsteroidal carcinogenic estrogen.
Hexestrol (HES), a synthetic nonsteroidal estrogen, is carcinogenic in Syrian golden hamsters. The major metabolite of HES is its… 
Highly Cited
1992
Highly Cited
1992
Synthesis and characterization of estrogen 2,3- and 3,4-quinones. Comparison of DNA adducts formed by the quinones versus horseradish peroxidase-activated catechol estrogens.
Catechol estrogens (CE) are among the major metabolites of estrone (E1) and 17 beta-estradiol (E2). Oxidation of these… 
Highly Cited
1992
Highly Cited
1992
Gas chromatography/mass spectrometry of catechol estrogens
Highly Cited
1990
Highly Cited
1990
The O-methylation of 4-hydroxyestradiol is inhibited by 2-hydroxyestradiol: implications for estrogen-induced carcinogenesis.
O-Methylation of catecholestrogens catalyzed by catechol-O-methyltransferase provides a major route for the rapid metabolic… 
Highly Cited
1990
Highly Cited
1990
Catechol estrogen formation in the mouse uterus and its role in implantation
Highly Cited
1983
Highly Cited
1983
Kinetics of catechol estrogen-estrogen receptor dissociation: A possible factor underlying differences in catechol estrogen biological activity
Highly Cited
1976
Highly Cited
1976
Convenient large scale preparation of catechol estrogens
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