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Estrogens, Catechol

Known as: Catechol estrogens, Catecholestrogens, Estrogens, Catechol [Chemical/Ingredient] 
2- or 4-Hydroxyestrogens. Substances that are physiologically active in mammals, especially in the control of gonadotropin secretion. Physiological… Expand
National Institutes of Health

Papers overview

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Review
2008
Review
2008
There is a clear association between the excessive exposure to estrogens and the development of cancer in hormone-sensitive… Expand
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Highly Cited
2001
Highly Cited
2001
The oxidative metabolism of 17beta-estradiol (E2) and estrone (E1) to catechol estrogens (2-OHE2, 4-OHE2, 2-OHE1, and 4-OHE1) and… Expand
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Review
2000
Review
2000
Estrogens induce tumors in laboratory animals and have been associated with breast and uterine cancers in humans. In relation to… Expand
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Highly Cited
2000
Highly Cited
2000
Catechol estrogens may mediate estrogen-induced carcinogenesis because 4-hydroxyestradiol induces DNA damage and renal tumors in… Expand
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Review
2000
Review
2000
  • J. Liehr
  • Endocrine reviews
  • 2000
  • Corpus ID: 16759666
The natural hormone 17 beta-estradiol (E2) induces tumors in various organs of rats, mice, and hamsters. In humans, slightly… Expand
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Highly Cited
1999
Highly Cited
1999
Catechol-O-methyltransferase (COMT, EC 2.1.1.6) is a ubiquitous enzyme that is crucial to the metabolism of carcinogenic… Expand
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Highly Cited
1997
Highly Cited
1997
Cancer is a disease that begins with mutation of critical genes: oncogenes and tumor suppressor genes. Our research on… Expand
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Highly Cited
1997
Highly Cited
1997
Mounting evidence suggests that catechol metabolites of estradiol may contribute to the development of estrogen-induced cancers… Expand
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Highly Cited
1986
Highly Cited
1986
Estradiol and other estrogens induce renal carcinoma in male Syrian hamsters. The mechanism of carcinogenesis still remains… Expand
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Highly Cited
1972
Highly Cited
1972
The substrate specificity of the catechol-O-methyltransferase, purified from human liver 380-fold, has been tested with a variety… Expand
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