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Estrogens, Catechol
Known as:
Catechol estrogens
, Catecholestrogens
, Estrogens, Catechol [Chemical/Ingredient]
2- or 4-Hydroxyestrogens. Substances that are physiologically active in mammals, especially in the control of gonadotropin secretion. Physiological…
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National Institutes of Health
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Related topics
Related topics
11 relations
Narrower (3)
4-hydroxyestradiol
6-hydroxyestrogen 6-sulfate
catechol estrogen 3,4-quinone
In Blood
Process of secretion
agonists
antagonists & inhibitors
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2001
Highly Cited
2001
Catechol-O-methyltransferase (COMT)-mediated metabolism of catechol estrogens: comparison of wild-type and variant COMT isoforms.
S. Dawling
,
Nady Roodi
,
R. Mernaugh
,
Xiaohong Wang
,
F. Parl
Cancer Research
2001
Corpus ID: 9778292
The oxidative metabolism of 17beta-estradiol (E2) and estrone (E1) to catechol estrogens (2-OHE2, 4-OHE2, 2-OHE1, and 4-OHE1) and…
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Review
2000
Review
2000
Estrogens as endogenous genotoxic agents--DNA adducts and mutations.
E. Cavalieri
,
K. Frenkel
,
J. Liehr
,
E. Rogan
,
D. Roy
Journal of the National Cancer Institute…
2000
Corpus ID: 26107340
Estrogens induce tumors in laboratory animals and have been associated with breast and uterine cancers in humans. In relation to…
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Highly Cited
2000
Highly Cited
2000
Induction of uterine adenocarcinoma in CD-1 mice by catechol estrogens.
R. Newbold
,
J. Liehr
Cancer Research
2000
Corpus ID: 12007701
Catechol estrogens may mediate estrogen-induced carcinogenesis because 4-hydroxyestradiol induces DNA damage and renal tumors in…
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Highly Cited
1999
Highly Cited
1999
Characterization and implications of estrogenic down-regulation of human catechol-O-methyltransferase gene transcription.
T. Xie
,
S. Ho
,
D. Ramsden
Molecular Pharmacology
1999
Corpus ID: 19870576
Catechol-O-methyltransferase (COMT, EC 2.1.1.6) is a ubiquitous enzyme that is crucial to the metabolism of carcinogenic…
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Highly Cited
1997
Highly Cited
1997
Molecular origin of cancer: catechol estrogen-3,4-quinones as endogenous tumor initiators.
E. Cavalieri
,
D. Stack
,
+10 authors
E. Rogan
Proceedings of the National Academy of Sciences…
1997
Corpus ID: 769506
Cancer is a disease that begins with mutation of critical genes: oncogenes and tumor suppressor genes. Our research on…
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Review
1996
Review
1996
Molecular mechanisms of estrogen carcinogenesis.
J. Yager
,
J. Liehr
Annual Review of Pharmacology and Toxicology
1996
Corpus ID: 44878731
In western society, the causes of several cancers--including breast, endometrium, ovary, liver, and prostate--have been linked to…
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Highly Cited
1994
Highly Cited
1994
Catechol-O-methyltransferase-catalyzed rapid O-methylation of mutagenic flavonoids. Metabolic inactivation as a possible reason for their lack of carcinogenicity in vivo.
B. Zhu
,
E. Ezell
,
J. Liehr
Journal of Biological Chemistry
1994
Corpus ID: 33133804
Highly Cited
1990
Highly Cited
1990
The antiestrogenic effect of cigarette smoking in women
J. Baron
,
C. Vecchia
,
F. Levi
1990
Corpus ID: 72723074
Review
1990
Review
1990
Free radical generation by redox cycling of estrogens.
J. Liehr
,
D. Roy
Free Radical Biology & Medicine
1990
Corpus ID: 1007998
Highly Cited
1972
Highly Cited
1972
Interactions between estrogens and catechol amines. 3. Studies on the methylation of catechol estrogens, catechol amines and other catechols by the ctechol-O-methyltransferases of human liver.
P. Ball
,
R. Knuppen
,
M. Haupt
,
H. Breuer
Journal of Clinical Endocrinology and Metabolism
1972
Corpus ID: 6782036
The substrate specificity of the catechol-O-methyltransferase, purified from human liver 380-fold, has been tested with a variety…
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