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4-demethylpenclomedine

Known as: 4-DM-PEN 
National Institutes of Health

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Picolines

Papers overview

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Review
2018
Review
2018
Abstract A086: Early clinical trial results for 4-demethyl-4-cholesteryloxycarbonylpenclomedine (DM-CHOC-PEN) in adolescents and young adults (AYA) with cancers
Background: 4-Demethyl-4-cholesteryloxycarbonylpenclomedine (DM-CHOC-PEN) is a poly-chlorinated pyridine cholesteryl carbonate… 
2016
2016
Abstract CT129: Phase II clinical trial results for 4-demethyl-4-cholesteryloxycarbonylpenclomedine (DM-CHOC-PEN) in NSCLC involving the CNS
Background: 4-Demethyl-4-cholesteryloxycarbonylpenclomedine (DM-CHOC-PEN) is a poly-chlorinated pyridine cholesteryl carbonate… 
2007
2007
Anticancer activities of carbonate and carbamate derivatives of 4-demethylpenclomedine
A280 4-DM-PEN is a non-neurotoxic metabolite of penclomedine (PEN) with anti-cancer properties. However, 4-DM-PEN does not… 
2005
2005
Thiolo-, thiono- and dithiocarbonate and thiocarbamate derivatives of demethylpenclomedine as novel anticancer agents
Purpose: The purpose of this investigation was to synthesize a series of thiolo-, thiono- and dithiocarbonate and thiocarbamate… 
1998
1998
The in vitro metabolism of penclomedine in mouse, rat, and human systems.
Penclomedine is a multi-chlorinated alpha-picoline derivative that has demonstrated activity in several murine breast cancer… 
1997
1997
4-Demethylpenclomedine, an antitumor-active, potentially nonneurotoxic metabolite of penclomedine.
Penclomedine [3,5-dichloro-4,6-dimethoxy-2-(trichloromethyl)pyridine], an antitumor agent, is currently in Phase I clinical… 
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