Corpus ID: 5377828

The in vitro metabolism of penclomedine in mouse, rat, and human systems.

@article{Hartman1998TheIV,
  title={The in vitro metabolism of penclomedine in mouse, rat, and human systems.},
  author={N. Hartman and K. U. Leo and T. G. Brewer and J. M. Strong},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1998},
  volume={26 6},
  pages={
          513-9
        }
}
  • N. Hartman, K. U. Leo, +1 author J. M. Strong
  • Published 1998
  • Biology, Medicine
  • Drug metabolism and disposition: the biological fate of chemicals
  • Penclomedine is a multi-chlorinated alpha-picoline derivative that has demonstrated activity in several murine breast cancer models and is currently in clinical testing for use against solid tumors. This study evaluates the metabolism of penclomedine in several in vitro hepatic models, including microsomes, fresh liver slices, and the isolated perfused rat liver (IPRL). Both human and mouse liver slices as well as human and mouse liver microsomes under aerobic conditions resulted in limited… CONTINUE READING
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