Abstract A086: Early clinical trial results for 4-demethyl-4-cholesteryloxycarbonylpenclomedine (DM-CHOC-PEN) in adolescents and young adults (AYA) with cancers

@article{Morgan2018AbstractAE,
  title={Abstract A086: Early clinical trial results for 4-demethyl-4-cholesteryloxycarbonylpenclomedine (DM-CHOC-PEN) in adolescents and young adults (AYA) with cancers},
  author={L. Morgan and A. H. Rodgers and R. Weiner and T. Mahmood and M. Ware and M. Bhandari and P. Friedlander},
  journal={Clinical Trials},
  year={2018}
}
  • L. Morgan, A. H. Rodgers, +4 authors P. Friedlander
  • Published 2018
  • Medicine
  • Clinical Trials
  • Background: 4-Demethyl-4-cholesteryloxycarbonylpenclomedine (DM-CHOC-PEN) is a poly-chlorinated pyridine cholesteryl carbonate with a MOA via bis-alkylation of DNA @ N7-guanine and N4-cytosine that has completed phase I and II trials in adult subjects with cancer that had +/- CNS involvement (AACR #1185, 2013; AACR #CT 129, 2017). The aims were to assess clinical responses, monitor toxicities/safety, and confirm MTDs for IV administered DM-CHOC-PEN (IND 68,876). We report here responses and… CONTINUE READING