Corpus ID: 87447914

Anticancer activities of carbonate and carbamate derivatives of 4-demethylpenclomedine

  title={Anticancer activities of carbonate and carbamate derivatives of 4-demethylpenclomedine},
  author={L. Morgan and R. Struck and W. R. Waud and B. S. Jursic and A. H. Rodgers and Blaise Leblanc},
  journal={Molecular Cancer Therapeutics},
  • L. Morgan, R. Struck, +3 authors Blaise Leblanc
  • Published 2007
  • Chemistry
  • Molecular Cancer Therapeutics
  • A280 4-DM-PEN is a non-neurotoxic metabolite of penclomedine (PEN) with anti-cancer properties. However, 4-DM-PEN does not readily cross the blood brain barrier and does not produce complete remissions in intracerebral (IC) gliomas. PEN did produce responses in clinical trials (gliomas - CR), but was neurotoxic and all trials ceased. DEKK-TEC and SRI have synthesized 20 carbonate and carbamate derivatives of 4-DM-PEN. Analogs prepared were from the series: 4-DM-PEN-4-OCO2-X & 4-DM-PEN-4-OCONH-X… CONTINUE READING