Thiolo-, thiono- and dithiocarbonate and thiocarbamate derivatives of demethylpenclomedine as novel anticancer agents

@article{Struck2005ThioloTA,
  title={Thiolo-, thiono- and dithiocarbonate and thiocarbamate derivatives of demethylpenclomedine as novel anticancer agents},
  author={R. Struck and W. Waud},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2005},
  volume={57},
  pages={180-184}
}
  • R. Struck, W. Waud
  • Published 2005
  • Chemistry, Medicine
  • Cancer Chemotherapy and Pharmacology
  • Purpose: The purpose of this investigation was to synthesize a series of thiolo-, thiono- and dithiocarbonate and thiocarbamate derivatives of 4-demethylpenclomedine (DM-PEN), the major plasma metabolite of penclomedine (PEN) in patients observed subsequently to be an active antitumor agent and non-neurotoxic in a rat model, in order to compare their antitumor activity with that of DM-PEN. Methods: Derivatives were prepared from DM-PEN and evaluated in vivo against human MX-1 breast tumor… CONTINUE READING
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