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4-amidinoindan-1-one 2'-amidinohydrazone

Known as: 4-AIAH 
 

Topic mentions per year

Topic mentions per year

1994-2008
012319942008

Related topics

Related topics

6 relations

Broader (4)

AmidinesAntineoplastic AgentsEnzyme InhibitorsIndans

Narrower (2)

CGP 48664SAM 486A

Related mentions per year

Related mentions per year

1942-2018
19401960198020002020
4-amidinoindan-1-one 2'-amidinohydrazone
Antineoplastic Agents
Enzyme Inhibitors
Amidines
CGP 48664
SAM 486A

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
Polyamine depletion with two different polyamine analogues causes DNA damage in human breast cancer cell lines.
It is well known that the positively charged polyamines have a DNA-stabilizing function and that polyamine depletion alters… (More)
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2000
2000
The organization of replicon clusters is not affected by polyamine depletion.
Earlier investigations have shown that polyamine depletion affects DNA replication negatively. DNA is synthesized in replicons… (More)
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1998
1998
In vitro manipulation of L1210 cell cycle kinetics with 4-amidinoindan-1-one 2'-amidinohydrazone, alpha-difluoromethylornithine and N1-acetylspermine.
We investigated whether in vitro L1210 growth inhibition by alpha-difluoromethylornithine (DFMO; 740 microM) and 4-amidinoindan-1… (More)
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1998
1998
In vivo manipulation of L1210 cell cycle phase distribution with alpha-difluoromethylornithine, 4-amidinoindan-1-one 2'-amidinohydrazone and N1-acetylspermine.
We investigated whether the in vivo growth inhibitory effect of the combination of 4-amidinoindan-1-one 2'-amidinohydrazone (CGP… (More)
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1997
1997
4-Amidinoindan-1-one 2'-amidinohydrazone (CGP 48664A) exerts in vitro growth inhibitory effects that are not only related to S-adenosylmethionine decarboxylase (SAMdc) inhibition.
The competitive S-adenosylmethionine decarboxylase (SAMdc; EC 4.1.1.50) inhibitor 4-amidinoindan-1-one 2'-amidinohydrazone (CGP… (More)
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1997
1997
CGP 48664, a potent and specific S-adenosylmethionine decarboxylase inhibitor: effects on regulation and stability of the enzyme.
Mammalian S-adenosylmethionine decarboxylase (AdoMetDC) catalyses a regulatory important step in the biosynthesis of polyamines… (More)
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1997
1997
Ordered cell cycle phase perturbations in Chinese hamster ovary cells treated with an S-adenosylmethionine decarboxylase inhibitor.
The polyamines putrescine, spermidine, and spermine are needed for normal cell cycle progression and polyamine-depleted cells… (More)
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1995
1995
In vivo growth inhibition of L1210 leukemia by 4-amidinoindan-1-one 2'-amidinohydrazone (CGP 48664A), a new inhibitor of S-adenosylmethionine decarboxylase.
We studied the in vivo growth-inhibitory effect of the new S-adenosylmethionine decarboxylase inhibitor 4-amidinoindan-1-one 2… (More)
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1995
1995
In vivo effects of 4-amidinoindan-1-one 2'-amidinohydrazone (CGP 48664A) and alpha-difluoromethylornithine (DFMO) on L1210 growth, cell-cycle phase distribution and polyamine contents.
We studied the in vivo effects of 4-amidinoindan-1-one 2'-amidinohydrazone (CGP 48664A), alpha-difluoromethylornithine (DFMO) and… (More)
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1994
1994
CGP 48664, a new S-adenosylmethionine decarboxylase inhibitor with broad spectrum antiproliferative and antitumor activity.
Inhibitors of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (SAMDC), derived from methylglyoxal-bis… (More)
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