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CGP 48664

Known as: CGP 48 664, CGP-48664A, CGP48664 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

4-amidinoindan-1-one 2'-amidinohydrazoneSardomozide
SAM 486A

Papers overview

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2006
2006
Mechanisms of allosteric regulation of Trypanosoma cruzi S-adenosylmethionine decarboxylase.
S-Adenosylmethionine decarboxylase (AdoMetDC) is a pyruvoyl-dependent enzyme that catalyzes an essential step in polyamine… 
2005
2005
Multi-centre Phase II trial of the polyamine synthesis inhibitor SAM486A (CGP48664) in patients with metastatic melanoma
SummaryPurpose: To determine the activity and tolerability of SAM496A, an inhibitor of S-adenosylmethionine decarboxylase (SAMDC… 
1998
1998
Lysosomal sequestration of polyamine analogues in Chinese hamster ovary cells resistant to the S-adenosylmethionine decarboxylase inhibitor, CGP-48664.
CGP-48664, an inhibitor of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (AdoMetDC), is presently… 
1998
1998
Human prostatic carcinoma cell lines display altered regulation of polyamine transport in response to polyamine analogs and inhibitors
The possibility was investigated that complex homeostatic mechanisms which maintain polyamine pools in prostate‐derived tumors… 
1997
1997
CGP 48664, a potent and specific S-adenosylmethionine decarboxylase inhibitor: effects on regulation and stability of the enzyme.
Mammalian S-adenosylmethionine decarboxylase (AdoMetDC) catalyses a regulatory important step in the biosynthesis of polyamines… 
Highly Cited
1997
Highly Cited
1997
Inhibition of polyamine synthesis influences contractility of intestinal smooth muscle in culture.
Smooth muscle strips from guinea pig ileum were cultured for 5 days and then tested for contractile properties to investigate… 
1995
1995
In vivo growth inhibition of leukemia by 4‐amidinoindan‐1‐one 2′‐amidinohydrazone (CGP 48664a), a new inhibitor of S‐adenosylmethionine decarboxylase
We studied the in vivo growth‐inhibitory effect of the new S‐adenosylmethionine decarboxylase inhibitor 4‐amidinoindan‐I‐one 2… 
1995
1995
in vivo effects of 4‐amidinoindan‐l‐one 2′‐amidinohydrazone (CGP 48664A) and α‐difluoromethylornithine (DFMO) on L1210 growth, cell‐cycle phase distribution and polyamine contents
We studied the in vivo effects of 4‐amidinoindan‐l‐one 2′‐amidinohydrazone (CGP 48664A), α‐difluoromethylornithine (DFMO) and a… 
Highly Cited
1994
Highly Cited
1994
CGP 48664, a new S-adenosylmethionine decarboxylase inhibitor with broad spectrum antiproliferative and antitumor activity.
Inhibitors of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (SAMDC), derived from methylglyoxal-bis… 
Highly Cited
1994
Highly Cited
1994
Effects of two novel bisphosphonates on bone cells in vitro.
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