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4'-demethylepipodophyllotoxin

Known as: 4'-demethyl epipodophyllotoxin, Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5R-(5alpha,5abeta,8aalpha,9beta))- 
National Institutes of Health

Related topics

Related topics

2 relations
analogs & derivatives

Broader (1)

podofilox

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Conjugates of podophyllotoxin and norcantharidin as dual inhibitors of topoisomeraseⅡ and protein phosphatase 2A.
2016
2016
Tertiary amine mediated targeted therapy against metastatic lung cancer.
2014
2014
Synthesis of 4β-acyloxypodophyllotoxin analogs modified in the C and E rings as insecticidal agents against Mythimna separata Walker.
2009
2009
Synthesis and biological evaluation of novel conjugates of podophyllotoxin and 5-FU as antineoplastic agents.
2008
2008
A fragmentation study of two compounds related to 4'-demethylepipodophyllotoxin in negative ion electrospray ionization by MSn ion-trap time-of-flight mass spectrometry.
High-resolution electrospray ionization multistage tandem mass spectrometry (MS 1-7) in negative ion mode was used to determine… 
1996
1996
Design, synthesis and topoisomerase II inhibition activity of 4'-demethylepipodophyllotoxin-lexitropsin conjugates.
The design and synthesis of 4'-demethylepipodophyllotoxin-lexitropsin conjugates capable of inhibiting the actions of… 
1994
1994
Site-specific DNA cleavage by Cu(II) complexes of podophyllotoxin derivatives.
1991
1991
Metal- and photo-induced cleavage of DNA by podophyllotoxin, etoposide, and their related compounds.
Podophyllotoxin (PD) and its derivative etoposide (VP-16), a clinically useful anticancer drug, exhibit different mechanisms of… 
1987
1987
Synthesis and structure-activity relationships among glycosidic derivatives of 4'-demethylepipodophyllotoxin and epipodophyllotoxin, showing VM26- and VP16-213-like activities.
We have synthesized acetal and ketal derivatives of 4'-demethylepipodophyllotoxin-beta-D-glucoside (DMEPG) and epipodophyllotoxin… 
Highly Cited
1983
Highly Cited
1983
Genetic, biochemical, and cross-resistance studies with mutants of Chinese hamster ovary cells resistant to the anticancer drugs, VM-26 and VP16-213.
The effects of the anticancer drugs 4′-demethylepipodophyllotoxin thenylidene β-d-glucoside and 4′-demethylepipodophyllotoxin… 
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