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4'-hydroxywarfarin

Known as: 4-hydroxy-3-(1-(4-hydroxyphenyl)-3-oxobutyl)-2H-1-benzopyran-2-one 
National Institutes of Health

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2 relations

Broader (1)

Warfarin
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Metabolism of R- and S-warfarin by CYP2C19 into four hydroxywarfarins.
Coumadin (R/S-warfarin) is a highly efficacious and widely used anticoagulant; however, its highly variable metabolism remains an… 
Highly Cited
1993
Highly Cited
1993
Correlation of human cytochrome P4502C substrate specificities with primary structure: warfarin as a probe.
The regio- and stereoselectivity of warfarin metabolism have been used to assess structure-function relationships of human P4502C… 
1992
1992
Phase II metabolism of warfarin in primary culture of adult rat hepatocytes.
We used adult rat hepatocytes in primary culture (HPC) as a model system to study the hepatic phase II metabolism of the… 
1991
1991
Selective inhibition of warfarin metabolism by diltiazem in humans.
Healthy men were administered i.v. racemic warfarin, S-warfarin or R-warfarin on two occasions, once in the drug-free state and… 
1991
1991
Evidence for the stability and cytochrome P450 specificity of the phenobarbital-induced reductive halothane-cytochrome P450 complex formed in rat hepatic microsomes.
1989
1989
Microbial models of mammalian metabolism: conversion of warfarin to 4'-hydroxywarfarin using Cunninghamella bainieri.
Warfarin, an anticoagulant and "metabolic probe" for cytochrome P-450 isozyme multiplicity, is metabolized to 4'-hydroxywarfarin… 
1979
1979
Warfarin enantiomer disposition: determination by stereoselective radioimmunoassay.
Immunoassay techniques offer promise for the selective analysis of enantiomeric substances without prior separation. In a… 
1975
1975
Studies of the microsomal drug metabolism system in warfarin-resistant and -susceptible rats.
Highly Cited
1970
Highly Cited
1970
The metabolism of 4-C14-warfarin sodium by the rat.
Warfarin and its metabolites were excreted by the rat in urine (two-thirds of the dose) and feces (one-third of the dose). For… 
Highly Cited
1969
Highly Cited
1969
Interaction of the anticoagulant drug warfarin and its metabolites with human plasma albumin.
The interaction of the anticoagulant drug warfarin and its metabolites with human plasma albumin was studied by equilibrium… 
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