24,25-Dihydroxyvitamin D 3

Known as: 9,10-Secocholesta-5,7,10(19)-triene-3,24,25-triol, (3beta,5Z,7E)-, 24,25 Dihydroxycholecalciferol, 9,10-Secocholesta-5,7,10(19)-Triene-3,24,25-Triol, (3-beta,5Z,7E)- 
A vitamin D derivative that is produced by the conversion of calcifediol by 1,25-dihydroxyvitamin D3 24-hydroxylase (CYP24A1). 24,25… (More)
National Institutes of Health

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24-hydroxyvitamin D3

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Bone Density Conservation AgentsVitamins
In BloodProcess of secretionagonistsanalogs & derivatives
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Papers overview

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2012
2012
The serum 24,25-dihydroxyvitamin D concentration, a marker of vitamin D catabolism, is reduced in chronic kidney disease
Chronic kidney disease is characterized, in part, as a state of decreased production of 1,25-dihydroxyvitamin D (1,25(OH)(2)D… (More)
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Highly Cited
2000
Highly Cited
2000
Deficient mineralization of intramembranous bone in vitamin D-24-hydroxylase-ablated mice is due to elevated 1,25-dihydroxyvitamin D and not to the absence of 24,25-dihydroxyvitamin D.
The 25-hydroxyvitamin D-24-hydroxylase enzyme (24-OHase) is responsible for the catabolic breakdown of 1,25-dihydroxyvitamin D [1… (More)
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Highly Cited
1995
Highly Cited
1995
Vitamin D receptor expression, 24-hydroxylase activity, and inhibition of growth by 1alpha,25-dihydroxyvitamin D3 in seven human prostatic carcinoma cell lines.
Although prostatic cancer is often viewed as an androgen-dependent malignancy, a number of other hormones including 1alpha, 25… (More)
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Highly Cited
1992
Highly Cited
1992
Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in mice.
Targeted disruption of the c-src proto-oncogene in mice has shown that src expression is required for normal bone resorption… (More)
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1987
1987
Synthesis in vitro of 1,25-dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3 by interferon-gamma-stimulated normal human bone marrow and alveolar macrophages.
Cultured human macrophages from normal donors were examined for their capability to metabolize 25-hydroxyvitamin D3 (25-(OH)D3… (More)
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Highly Cited
1986
Highly Cited
1986
1,25-Dihydroxyvitamin D3 production by human keratinocytes. Kinetics and regulation.
Human foreskin keratinocytes in vitro metabolize 25-hydroxyvitamin D3 to a number of metabolites, including 1,25-dihydroxyvitamin… (More)
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Highly Cited
1985
Highly Cited
1985
Regulation by vitamin D metabolites of messenger ribonucleic acid for preproparathyroid hormone in isolated bovine parathyroid cells.
We have recently determined that high calcium concentrations, in parallel with their suppressive effects on parathyroid hormone… (More)
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1981
1981
Impaired 24,25-dihydroxyvitamin D production in anephric human and pig.
Plasma 25-hydroxyvitamin D and 24, 25-dihydroxy-vitamin D [24,25-(OH)(2)D] concentrations were measured in normal and chronically… (More)
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1981
1981
Human bone cells in culture metabolize 25-hydroxyvitamin D3 to 1,25-dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3.
Bone cells respond to 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) for mineral mobilization and contain receptors for 1,25(OH)2D3. We… (More)
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Highly Cited
1979
Highly Cited
1979
1α, 25-Dihydroxyvitamin D3, and 24,25-dihydroxyvitamin D3 in vitro synthesis by human decidua and placenta
The biologically active metabolite of vitamin D, 1α, 25-dihydroxyvitamin D (1α, 25(OH)2D), is synthesised by successive… (More)
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