R. Horst

Publications414
h-index76
Citations21,538
Highly Influential Citations885
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Physiological changes at parturition and their relationship to metabolic disorders.
TLDR
Three basic physiological functions must be maintained during the periparturient period if disease is to be avoided: adaptation of the rumen to lactation diets that are high in energy density, maintenance of normocalcemia, and maintenance of a strong immune system.
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Genome-wide association study of circulating vitamin D levels
TLDR
Strong genome-wide significant associations with 25(OH)D are confirmed through meta-analysis with the GWAS data for GC, NADSYN1/DHCR7, CYP2R1 and CYP 2R1, but not C10orf88, the key C-25 hydroxylase that converts vitamin D3 to an active vitamin D receptor ligand.
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Prevalence of subclinical hypocalcemia in dairy herds.
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Strategies for preventing milk fever in dairy cattle.
TLDR
This report discusses various practical strategies and potential research areas for managing the dietary forage components to minimize the effects of K on milk fever incidence.
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Effects of the addition of potassium or sodium, but not calcium, to prepartum ratios on milk fever in dairy cows.
TLDR
It is demonstrated that dietary Ca concentration is not a major risk factor for milk fever and that dietary strong cations, especially K, induce metabolic alkalosis in the prepartum dairy cow, which reduces the ability of the cow to maintain Ca homeostasis.
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Biochemical evaluation of patients with cancer-associated hypercalcemia: evidence for humoral and nonhumoral groups.
TLDR
The data suggest that elevated excretion of nephrogenous cyclic AMP may be a useful marker of humorally mediated cancer-associated hypercalcemia, that this type of hypercalccemia is common, that the humoral factor responsible for this syndrome is not native 1-84 parathyroid hormone, and that the various subtypes of cancer- associated hyperCalcemia are biochemically distinguishable from primary hyperparathyroidism.
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Effects of altering dietary cation-anion difference on calcium and energy metabolism in peripartum cows.
TLDR
Feeding of anionic salts plus CaCO3 to reduce DCAD to -15 and increase Ca in prepartum diets prevents hypocalcemia at calving in cows, but decreases prepartu dry matter intake and increases the concentration of liver triglyceride in heifers.
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Calcium and vitamin D metabolism in the dairy cow.
TLDR
Vitamin D and calcium metabolism is reviewed, giving emphasis to 1,25-dihydroxyvitamin D receptor regulation and function as related to the periparturient dairy cow, providing insights into nutritional and endocrine strategies that have proved useful in milk fever management.
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Regulation of calcium and phosphorus homeostasis in the dairy cow.
  • R. Horst
  • Chemistry, Medicine
    Journal of dairy science
  • 1 February 1986
TLDR
The mechanism of calcium and phosphorus homeostasis in dairy cows is described to provide a clearer understanding of the rationale behind current management and supplementation practices and the need to keep prepartum dietary calcium intake at less than or equal to 50 g/d to minimize the incidence of milk fever is addressed.
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Regulation of L‐selectin and CD18 on bovine neutrophils by glucocorticoids: effects of cortisol and dexamethasone
TLDR
The results strongly suggest that one mechanism of the anti‐inflammatory action of glucocorticoids is to induce dramatic down‐regulation of L‐selectin and CD18 adhesion molecules on blood neutrophils.
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