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2-hydroxyestrone

Known as: Estra-1,3,5(10-trien-17-one, 2,3-dihydroxy)-, 2-OHE(1), Estra-1,3,5(1)-Trien-17-One, 2,3-Dihydroxy- 
A metabolite formed during the catabolism of estrone by the liver through the hydroxylation of the carbon at position 2 by cytochrome P450 (CYP… 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

Anticarcinogenic AgentsHydroxyestrones
NCIt Antineoplastic Agent Terminology

Papers overview

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2001
2001
COMT Isoforms Catechol Estrogens : Comparison of Wild-Type and Variant-Methyltransferase ( COMT )-mediated Metabolism of O Catechol-Updated Version
The oxidative metabolism of 17 -estradiol (E2) and estrone (E1) to catechol estrogens (2-OHE2, 4-OHE2, 2-OHE1, and 4-OHE1) and… 
1984
1984
Suppression of the preovulatory luteinizing hormone surge in the rat by 2-hydroxyestrone: relationship to endogenous estradiol levels.
Injection of 100 micrograms 2-hydroxyestrone (2OHE1) at various times on the morning of proestrus into normal 4-day-cycling rats… 
1983
1983
Radioimmunoassay of 2-hydroxyestrone in plasma during the estrous cycle of the rat: interrelationships with estradiol, progesterone, and the gonadotropins.
A RIA for 2-hydroxyestrone (2-OHE1) in rat plasma has been developed. The assay employs an antiserum that is specific for… 
1983
1983
Metabolism of 2-methoxyestrone in normal men.
We studied, in four normal men, the metabolism of 2-methoxyestrone (2-MeOE1) using pulse injections of either [3H]2MeOE1 (two men… 
1982
1982
Metabolic clearance rate and conversion ratios of [3H]2-hydroxyestrone in normal men.
The metabolism of 2-hydroxyestrone (2-OHE1) was studied in eight normal men with pulse injections of [6,7-3H]2-OHE1 (four… 
1982
1982
2-Hydroxyestrone suppresses and 2-methoxyestrone augments the preovulatory prolactin surge in the cycling rat.
The nonuterotropic metabolite of estradiol, 2-hydroxyestrone, administered at noon of proestrus to four-day cycling rats… 
1982
1982
The effect of catecholestrogens on the growth of prolactin-secreting pituitary tumors and normal prolactin synthesis in the rat.
The effects of the catecholestrogens 2-hydroxyestrone (2-OHE1) and 2-hydroxyestradiol (2-OHE2) on the growth of the estrogen… 
1981
1981
Stimulation of release of luteinizing hormone from cultured pituitary cells by 2- and 4-hydroxylated oestrogens.
We have examined the effect of the catechol oestrogens 2-hydroxyoestradiol (2-OHE2), 4-hydroxyoestradiol (4-OHE2) and 2… 
Review
1978
Review
1978
Impeding estrogens and the etiology of breast cancer.
Abstract The partial agonistic role of impeding estrogens is further described. Synthesis of progesterone receptor, induced with… 
Highly Cited
1976
Highly Cited
1976
Catechol estrogen formation by the human fetal brain and pituitary.
Homogenates of central neuroendocrine tissues from 2 male and 1 female midtrimester fetuses were incubated with (23H) estradiol…