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Petrosal sinus sampling with and without corticotropin-releasing hormone for the differential diagnosis of Cushing's syndrome.
- E. Oldfield, J. Doppman, +5 authors D. Loriaux
- The New England journal of medicine
- 26 September 1991
Simultaneous bilateral sampling of plasma from the inferior petrosal sinuses, with the adjunctive use of CRH, distinguishes patients with Cushing's disease from those with ectopic adrenocorticotropin secretion with high diagnostic accuracy. Expand
Acute hypothalamic-pituitary-adrenal responses to the stress of treadmill exercise. Physiologic adaptations to physical training.
It is concluded that physical conditioning is associated with a reduction in pituitary-adrenal activation in response to a given workload and Alterations of the hypothalamic-pituitary and adrenal axis consistent with mild hypercortisolism and similar to findings in depression and anorexia nervosa were found only in highly trained runners. Expand
Perioperative Glucocorticoid Coverage A Reassessment 42 Years After Emergence of a Problem
Clinical and experimental evidence support the concept that the current amount of perioperative glucocorticoid coverage is excessive and has been based on anecdotal information. Expand
Adrenarche: a survey of rodents, domestic animals, and primates.
- G. Cutler, M. Glenn, M. Bush, G. Hodgen, C. Graham, D. Loriaux
- Biology, Medicine
- 1 December 1978
It is apparent that adrenal androgen levels and their developmental patterns differ markedly among species, and that among the species examined, only the chimpanzee exhibits an adrenarche comparable to that of man. Expand
Abnormal hypothalamic-pituitary-adrenal function in anorexia nervosa. Pathophysiologic mechanisms in underweight and weight-corrected patients.
In underweight anorexics, the pituitary responds appropriately to corticotropin-releasing hormone, being restrained in its response by the elevated levels of cortisol, which suggests that hypercortisolism in anorexia nervosa reflects a defect at or above the hypothalamus. Expand
Preoperative lateralization of ACTH-secreting pituitary microadenomas by bilateral and simultaneous inferior petrosal venous sinus sampling.
- E. Oldfield, G. Chrousos, +6 authors J. Doppman
- The New England journal of medicine
- 10 January 1985
The utility of selective catheterization of the inferior petrosal sinus for determination of plasma ACTH concentrations in the diagnosis of pituitary-dependent hypercortisolism is established and simultaneous sampling of bilateral venous blood should provide a means of localizing the microadenoma in one side of the pituitaries. Expand
Psychiatric implications of basic and clinical studies with corticotropin-releasing factor.
Clinically, experience in administering ovine CRF shows that CRF can be helpful in resolving differential diagnostic dilemmas in patients with various disorders of the hypothalamic-pituitary-adrenal axis and in furthering an understanding of the pathophysiology of conditions such as Cushing's disease and depression. Expand
Responses to corticotropin-releasing hormone in the hypercortisolism of depression and Cushing's disease. Pathophysiologic and diagnostic implications.
The pathophysiologic features of hypercortisolism in depression and Cushing's disease are distinct in each of the disorders and that the ovine corticotropin-releasing hormone stimulation test can be helpful in their differential diagnosis. Expand
Cimetidine is an antiandrogen in the rat.
Cimetidine is a nonsteroidal-antiandrogen and this property may contribute to the production of gynecomastia in cimetidine-treated men, which is linked to the development of breast enlargement in men. Expand
EFFECTS OF HUMAN PANCREATIC TUMOUR GROWTH HORMONE RELEASING FACTOR ON GROWTH HORMONE AND SOMATOMEDIN C LEVELS IN PATIENTS WITH IDIOPATHIC GROWTH HORMONE DEFICIENCY
Human pancreatic tumour growth hormone releasing factor may be useful in distinguishing pituitary disease from hypothalamic disease and serum somatomedin C levels may increase without a change in serum immunoreactive GH concentrations after hpGRF-40 administration. Expand