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2-amino-1,3,4-thiadiazole

Known as: Aminothiadiazole, Amino 134-Thiadiazole, 1,3, 4-Thiadiazole, 2-amino- (8CI) 
A synthetic derivative of nicotinamide adenine dinucleotide (NAD). Aminothiadiazole competitively inhibits inosine 5-monophosphate dehydrogenase… 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

Antineoplastic AgentsThiadiazoles

Narrower (1)

NSC 4728

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Comparison of the hydrogen-bond patterns in 2-amino-1,3,4-thiadiazolium hydrogen oxalate, 2-amino-1,3,4-thiadiazole-succinic acid (1/2), 2-amino-1,3,4-thiadiazole-glutaric acid (1/1) and 2-amino-1,3…
The X-ray single-crystal structure determinations of the chemically related compounds 2-amino-1,3,4-thiadiazolium hydrogen… 
2012
2012
14-Aminotetradecanoic acid exhibits antioxidant activity and ameliorates xenobiotics-induced cytotoxicity
Natural compounds with free-radical scavenging activity have potential role in maintaining human health and preventing diseases… 
2011
2011
The activity of a new 2-amino-1,3,4-thiadiazole derivative 4ClABT in cancer and normal cells.
The 2-amino-5-(2,4-dihydroxyphenyl)-1,3,4-thiadiazole set are well known compounds with interesting in vitro and in vivo anti… 
2004
2004
Clinical and clinical pharmacologic studies of 2-amino-1,3,4-thiadiazole (A-TDA:NSC 4728)
SummaryA clinical phase I–II evaluation of 2-amino-1,3,4-thiadiazole (A-TDA) administered daily, twice a week, or weekly was… 
2001
2001
2-Amino-5-methyl-1,3,4-thiadiazole and 2-amino-5-ethyl-1,3,4-thiadiazole.
The structures of 2-amino-5-methyl-1,3,4-thiadiazole, C(3)H(5)N(3)S, and 2-amino-5-ethyl-1,3,4-thiadiazole, C(4)H(7)N(3)S, have… 
1995
1995
Aminothiadiazole in the Treatment of Advanced Leiomyosarcoma of the Uterine Corpus: A Gynecologic Oncology Group Study
Aminothiadiazole was used to treat 21 patients with metastatic or recurrent leiomyosarcoma of the uterus. All patients received a… 
1989
1989
Aminothiadiazole (NSC 4728) in Patients with Advanced Nonsquamous Carcinoma of the Cervix: A Phase II Study of the Gynecologic Oncology Group
Twenty-six evaluable patients with advanced nonsquamous cell cervical cancer were treated with aminothiadiazole at a dosage of… 
1979
1979
Pharmacokinetic model for 2-amino-1,3,4-thiadiazole in mouse, dog, and monkey.
A mathematic model has been developed to describe the time course of 2-amino-1,3,4-thiadiazole and its metabolites in the serum… 
1973
1973
DNA synthesis inhibition, cytotoxicity and their relationship to teratogenesis following administration of a nicotinamide antagonist, aminothiadiazole, to pregnant rats.
Four groups of Wistar rats were treated with 100 mg/kg aminothiadiazole (ATD) i.p. on day 12 of gestation. The first group was… 
1960
1960
Effects of nicotinamide and related compounds on the antileukemic activity of 2-amino-1,3,4-thiadiazole.
The effect of nicotinamide and a variety of nicotinamide analogs and related compounds on the activity of 2-amino-1,3,4… 
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