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NSC 4728

Known as: NSC-4728 
National Institutes of Health

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2-amino-1,3,4-thiadiazole

Papers overview

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2007
2007
Synthesis of 2-Acylamino, 2-Aroylamino and Ethoxycarbonyl Imino-1,3,4-thiadiazoles as Antitumor Agents
2-Amino-1,3,4-thiadiazoles compounds (2a-e) were obtained from the reaction of thiosemi carbazide with 2… 
2004
2004
The pharmacologic fate of the antitumor agent 2-amino-1,3,4-thiadiazole in the dog
SummaryAnticipating the renewed clinical trial of the antitumor agent 2-amino-1,3,4-thiadiazole (AT, NSC-4728), we have studied… 
2004
2004
Clinical and clinical pharmacologic studies of 2-amino-1,3,4-thiadiazole (A-TDA:NSC 4728)
SummaryA clinical phase I–II evaluation of 2-amino-1,3,4-thiadiazole (A-TDA) administered daily, twice a week, or weekly was… 
1990
1990
Aminothiadiazole (NSC 4728) in Patients with Advanced Carcinoma of the Endometrium: A Phase II Study of the Gynecologic Oncology Group
Twenty-one evaluable patients with advanced carcinoma of the endometrium were treated with aminothiadiazole at a dosage of 125 mg… 
1989
1989
Aminothiadiazole (NSC 4728) in Patients with Advanced Nonsquamous Carcinoma of the Cervix: A Phase II Study of the Gynecologic Oncology Group
Twenty-six evaluable patients with advanced nonsquamous cell cervical cancer were treated with aminothiadiazole at a dosage of… 
1988
1988
Phase II trials of 5-day vinblastine infusion (NSC 49842), L-alanosine (NSC 153353), acivicin (NSC 163501), and aminothiadiazole (NSC 4728) in patients with recurrent or metastatic renal cell…
SummaryOne hundred and forty-four evaluable patients with recurrent or metastatic renal cell carcinoma (RCC) were treated with… 
1986
1986
Aminothiadiazole (NSC 4728) in Patients with Advanced Ovarian Carcinoma A Phase II Study of the Gynecologic Oncology Group
Thirty-two evaluable patients with advanced epithelial ovarian cancer were treated with aminothiadiazole at a dosage of 125 mg/m2… 
1982
1982
Liquid chromatographic separation and quantitation of 2-amino-1,3,4-thiadiazole (NSC-4728) from human and murine serum.
1977
1977
Mechanism of action of 2-amino-1,3,4-thiadiazole (NSC 4728).
The synthesis and isolation of two derivatives of 2-amino-1,3,4-thialdiazole(aminothiadiazole) are described. The derivatives are… 
Highly Cited
1976
Highly Cited
1976
Effects of 2-amino-1,3,4-thiadiazole on ribonucleotide pools of leukemia L1210 cells.
The effects of 2-amino-1,3,4-thiadiazole [aminothiadiazole (NSC 4728)] on purine and pyrimidine ribonucleotide pools of L1210… 
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