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2-(allylthio)pyrazine

 
National Institutes of Health

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3 relations

Broader (3)

Cytochrome P-450 CYP2E1 InhibitorsEnzyme InhibitorsPyrazines

Papers overview

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2009
2009
Preparation and evaluation of 2-(allylthio)pyrazine-loaded lipid emulsion with enhanced stability and liver targeting.
To develop 2-(allylthio)pyrazine (2-AP)-loaded lipid emulsion for parenteral administration, various lipid emulsions were… Expand
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2001
2001
2-(Allylthio)pyrazine, a cancer chemopreventive agent, inhibits liver fibrosis induced by dimethylnitrosamine in rats: role of inhibition of transforming growth factor-beta1 expression.
Exposure to nitrosamines may be the occupational risk factor for liver cirrhosis. 2-(Allylthio)pyrazine, a chemopreventive agent… Expand
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Review
1999
Review
1999
Update from Asia. Asian studies on cancer chemoprevention.
  • T. Yun
  • Annals of the New York Academy of Sciences
  • 1999
    • Corpus ID: 9281144
In Asia, nontoxic dietary products are considered desirable primary prevention vehicles for conquering cancer. As early as 1978… Expand
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Review
1999
Review
1999
Chemopreventive effects of 2-(Allylthio)pyrazine
A series of organosulfur compounds were synthesized with the aim of developing chemopreventive compounds active against… Expand
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1999
1999
Effect of a new chemoprotective agent, 2-(allylthio)pyrazine, on the pharmacokinetics of intravenous theophylline in rats.
The effect of 2-(allylthio)pyrazine (2-AP) pretreatment on the pharmacokinetics of theophylline and its metabolites was… Expand
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1999
1999
2-(Allylthio)pyrazine inhibition of aflatoxin B1-induced hepatocarcinogenesis in rats.
2-(Allylthio)pyrazine (2-AP), a synthetic pyrazine derivative with an allylsulfur moiety, has hepatoprotective effects against… Expand
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1998
1998
Chemopreventive effects of 2-(allylthio)pyrazine on hepatic lesion, mutagenesis and tumorigenesis induced by vinyl carbamate or vinyl carbamate epoxide.
2-(Allylthio)pyrazine (2-AP), synthesized for its possible use as a hepatoprotective agent, has been found to selectively inhibit… Expand
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1998
1998
Metabolic changes of acetaminophen after intravenous administration to rats pretreated with 2-(allylthio)pyrazine.
Keywords: acetaminophen; 2-(allylthio)pyrazine; glucuronide; sulphate; glutathione; mercapturate; cysteine conjugates of… Expand
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1998
1998
2-(allylthio)pyrazine inhibition of aflatoxin B1-induced hepatotoxicity in rats: inhibition of cytochrome P450 2B- and 3A2-mediated bioactivation.
2-(Allylthio)pyrazine (2-AP), a synthetic organosulfur compound, exhibits hepatoprotective and chemopreventive effects. The… Expand
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1997
1997
Inhibition of cytochrome P450 2E1 expression by 2-(allylthio)pyrazine, a potential chemoprotective agent: hepatoprotective effects.
Cytochrome P450 2E1 (P450 2E1) is active in both the detoxification and activation of small organic molecules. The effects of 2… Expand
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