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Prevalence and risk of cancer of focal thyroid incidentaloma identified by 18F-fluorodeoxyglucose positron emission tomography for metastasis evaluation and cancer screening in healthy subjects.
F focal thyroid FDG-PET incidentaloma with highSUVs warrants a pathological diagnostic procedure if it changes a patient's treatment plan or prognosis, especially in cases with high SUVs.
Molecular mechanism of nrf2 activation by oxidative stress.
It is reported that PI3-kinase is responsible for the rise of cellular Ca(2+), which is requisite for nuclear translocation of Nrf2 and contributes to antioxidant phase II enzyme induction via coordinate gene transactivation.
Glutathione S-Transferase Mu Modulates the Stress-activated Signals by Suppressing Apoptosis Signal-regulating Kinase 1*
Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase kinase kinase that can activate the c-Jun N-terminal kinase and the p38 signaling pathways. It plays a critical role
A Prospective Evaluation of 18F-FDG and 11C-Acetate PET/CT for Detection of Primary and Metastatic Hepatocellular Carcinoma
The addition of 11C-acetate to 18F-FDG PET/CT increases the overall sensitivity for the Detection of primary HCC but not for the detection of extrahepatic metastases.
Phosphatidylinositol 3-kinase regulates nuclear translocation of NF-E2-related factor 2 through actin rearrangement in response to oxidative stress.
It is demonstrated that the PI3-kinase signaling pathway regulates rearrangement of actin microfilaments in response to oxidative stress and that depolymerization of act in causes a complex of Nrf2 bound with actin to translocate into nucleus.
Effects of quercetin on the bioavailability of doxorubicin in rats: Role of CYP3A4 and P-gp inhibition by quercetin
It appears that the development of oral doxorubicin preparations is possible, which will be more convenient than the intravenous dosage forms, and concurrent use of quercetin provides a therapeutic benefit — it increases the bioavailability of doxorbicin administered orally.
Somatic Mutation of p53 Leads to Estrogen Receptor α-Positive and -Negative Mouse Mammary Tumors with High Frequency of Metastasis
This tumor system reproduces many important features of human breast cancer and provides tools for the study of the origins of ERα-positive and -negative breast tumors in mice.
Preparation and characterization of solid lipid nanoparticles loaded with doxorubicin.
Prognostic Value of Metabolic Tumor Volume and Total Lesion Glycolysis in Head and Neck Cancer: A Systematic Review and Meta-Analysis
Despite clinically heterogeneous HNC and the various methods adopted between studies, it can confirm that patients with a high MTV or TLG have a higher risk of adverse events or death.
The essential role of phosphatidylinositol 3-kinase and of p38 mitogen-activated protein kinase activation in the antioxidant response element-mediated rGSTA2 induction by decreased glutathione in
Data showed that PI3-kinase plays an essential role in the ARE-mediated rGSTA2 induction by oxidative stress after SAAD, which activates the p38 MAP kinase and leads to rGstA 2 induction.