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2',6'-pipecoloxylidide

Known as: 2-piperidinecarboxamide, N-(2,6-dimethylphenyl)-, Desbutylbupivacaine, pipecolylxylidine-2',6' 
National Institutes of Health

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2 relations

Broader (1)

Bupivacaine
analogs & derivatives

Papers overview

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2011
2011
Population pharmacokinetic analysis of ropivacaine and its metabolite 2',6'-pipecoloxylidide from pooled data in neonates, infants, and children.
BACKGROUND The aim was to characterize ropivacaine and 2',6'-pipecoloxylidide (PPX) pharmacokinetics and factors affecting them… 
2006
2006
Effects of premedication medicines on the formation of the CYP3A4-dependent metabolite of ropivacaine, 2', 6'-Pipecoloxylidide, on human liver microsomes in vitro.
Ropivacaine is a relatively new amide-type local anaesthetic, mainly used for surgery and postoperative pain relief. In this… 
1999
1999
Stereoselective urinary excretion of bupivacaine and its metabolites during epidural infusion.
A sensitive and efficient chiral assay for bupivacaine and its three principal metabolites desbutylbupivacaine, 4… 
Highly Cited
1996
Highly Cited
1996
Ropivacaine, a new amide-type local anesthetic agent, is metabolized by cytochromes P450 1A and 3A in human liver microsomes.
Ropivacaine is a new amide-type local anesthetic agent. Unlike bupivacaine and mepivacaine, two structurally similar local… 
1995
1995
Kinetics of bupivacaine after clonidine pretreatment in mice
Previous studies have reported that clonidine pretreatment causes an increase in the local anaesthetic activity of bupivacaine… 
Highly Cited
1995
Highly Cited
1995
Metabolism of a New Local Anesthetic, Ropivacaine, by Human Hepatic Cytochrome P450
Background Ropivacaine is a local anesthetic with a long duration of action. Although it is less toxic than bupivacaine, local… 
1994
1994
Cigarette smoke increases bupivacaine metabolism in rats
This study was designed to document possible changes in bupivacaine kinetics in rats after exposure to cigarette smoke. Rats (n… 
1991
1991
Cumulation of bupivacaine, desbutylbupivacaine and 4‐hydroxybupivacaine during and after continuous interscalene brachial plexus block
Desbutylbupivacaine (DBB) and 4‐hydroxybupivacaine (4‐OHB) are major metabolites of bupivacaine. They may cumulate during… 
1991
1991
Plasma concentrations of bupivacaine and two of its metabolites during continuous interscalene brachial plexus block.
An interscalene brachial plexus block was performed via a catheter with 20-28 ml of 0.75% bupivacaine plus adrenaline for surgery… 
1988
1988
Lack of effect of cimetidine on the pharmacokinetics of bupivacaine in healthy subjects.
1. The possibility of a pharmacokinetic interaction between the H2-receptor antagonist cimetidine and the long-acting local… 
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