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Maximum Recommended Doses of Local Anesthetics: A Multifactorial Concept
TLDR
Conditions (eg, end-stage pregnancy, high age in epidural, or spinal block) or diseases (uremia) that may increase the rate of the initial uptake of the local anesthetic are indications to reduce the dose in comparison to one normally used for young, healthy, and nonpregnant adults. Expand
Preincisional paravertebral block reduces the prevalence of chronic pain after breast surgery.
TLDR
In addition to providing acute postoperative pain relief, preoperative PVB seems to reduce the prevalence of chronic pain 1 yr after breast cancer surgery. Expand
Single-Injection Paravertebral Block Before General Anesthesia Enhances Analgesia After Breast Cancer Surgery With and Without Associated Lymph Node Biopsy
TLDR
Paravertebral block before general anesthesia for breast cancer surgery reduced postoperative pain, opioid consumption, and occurrence of PONV and improved recovery from anesthesia. Expand
Acute opioid effects on human brain as revealed by functional magnetic resonance imaging
TLDR
It is demonstrated that functional magnetic resonance imaging can provide information of brain regions involved in opioid-induced central nervous system effects and the cingulate, orbitofrontal, posterior parietal and insular cortices, and amygdala showed activation, which was temporally closely related to most subjective sensations. Expand
Morphine and oxycodone in the management of cancer pain: plasma levels determined by chemical and radioreceptor assays.
TLDR
Results from RRA indicate that oxycodone in vivo is a potent mu-agonist and that at least part of its analgesic action is mediated by active metabolites, thus suggesting their complex interactions in vivo. Expand
High‐dose bupivacaine, levobupivacaine and ropivacaine in axillary brachial plexus block
TLDR
The drugs were compared in brachial plexus block for the first time in the same randomized and double‐blind study. Expand
Postdischarge Symptoms After Ambulatory Surgery: First-Week Incidence, Intensity, and Risk Factors
TLDR
Longer duration of surgery led to increased likelihood of pain and nausea in all patients and increased the risk of several other symptoms in adults and older children, and women were more prone to experience minor morbidity. Expand
Controlled Release of Lidocaine from Injectable Gels and Efficacy in Rat Sciatic Nerve Block
TLDR
Poloxamer gel proved to be the most promising carrier for lidocaine in the use of low-viscosity gels in prolonging the release of lidocane in rats. Expand
Intrathecal morphine-3-glucuronide does not antagonize spinal antinociception by morphine or morphine-6-glucuronide in rats.
TLDR
Estimated ED50 from the dose-response curves for morphine and morphine-6-glucuronide showed about a 30 times more potent antinociceptive effect of morphine- 6-glUCuronide compared with morphine. Expand
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