Bupivacaine

Known as: dl-1-Butyl-2',6'-pipecoloxylidide, racemic bupivacaine, 2-Piperidinecarboxamide, 1-butyl-N-(2,6-dimethylphenyl)- 
An amide-type, long-acting local anesthetic. Bupivicaine reversibly binds to specific sodium ion channels in the neuronal membrane, resulting in a… (More)
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
BACKGROUND Caudal block is a common technique for paediatric analgesia but with the disadvantage of short duration of action… (More)
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Highly Cited
2008
Highly Cited
2008
We have studied the effects of bupivacaine on human and bovine articular chondrocytes in vitro. Time-lapse confocal microscopy of… (More)
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Highly Cited
2006
Highly Cited
2006
The patient was a 58-yr-old, 82-kg, 170-cm male who presented for arthroscopic repair of a torn rotator cuff in the right… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND AND OBJECTIVES Infusion of a lipid emulsion has been advocated for treatment of severe bupivacaine cardiac toxicity… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND The purpose of this study was to compare the onset and duration of sensory and motor block, as well as the hemodynamic… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND AND OBJECTIVES We previously demonstrated in rats that intravenous infusion of a lipid emulsion increases survival in… (More)
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Highly Cited
2002
Highly Cited
2002
We have investigated the effects of the myotoxic local anesthetic bupivacaine on rat skeletal muscle mitochondria and isolated… (More)
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Highly Cited
2002
Highly Cited
2002
UNLABELLED Levobupivacaine is the pure S(-)-enantiomer of racemic bupivacaine but is less toxic to the heart and central nervous… (More)
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Highly Cited
1997
Highly Cited
1997
We have compared the incidence of CNS symptoms and changes in echocardiography and electrophysiology during i.v. infusions of… (More)
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Highly Cited
1989
Highly Cited
1989
The acute central nervous and cardiovascular effects of the local anesthetics ropivacaine and bupivacaine were compared in 12… (More)
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