• Publications
  • Influence
Population pharmacokinetics.
  • L. Aarons
  • Medicine
  • International journal of clinical pharmacology…
  • 1992
Traditionally pharmacokinetic studies have been performed in small homogenous groups of subjects, often normal healthy, young male volunteers. These studies are well controlled and generateExpand
  • 105
  • 10
Software for Population Pharmacokinetics and Pharmacodynamics
  • L. Aarons
  • Medicine
  • Clinical pharmacokinetics
  • 1 April 1999
Pharmacokinetic-pharmacodynamic modelling is being used increasingly as a tool in drug development because often in phase III clinical trials only sparse data are available for analysis and so aExpand
  • 87
  • 9
Mefloquine Pharmacokinetic-Pharmacodynamic Models: Implications for Dosing and Resistance
ABSTRACT Antimalarial resistance develops and spreads when spontaneously occurring mutant malaria parasites are selected by concentrations of antimalarial drug which are sufficient to eradicate theExpand
  • 123
  • 8
Mixed Effects Models for the Population Approach: Models, Tasks, Methods, and Tools
  • L. Aarons
  • Medicine
  • CPT: Pharmacometrics & Systems Pharmacology
  • 1 January 2015
Reviewed by L Aarons At the end of this review I am required to declare any conflicts of interest and I am going to say none. However, I have known Marc Laveille for some time and had manyExpand
  • 43
  • 7
Combining the ‘bottom up’ and ‘top down’ approaches in pharmacokinetic modelling: fitting PBPK models to observed clinical data
Pharmacokinetic models range from being entirely exploratory and empirical, to semi‐mechanistic and ultimately complex physiologically based pharmacokinetic (PBPK) models. This choice is conditionalExpand
  • 127
  • 6
Population dynamics of untreated Plasmodium falciparum malaria within the adult human host during the expansion phase of the infection.
A retrospective analysis was performed of parasite count data recorded from the first 7 days of blood or mosquito transmitted Plasmodium falciparum infections given for the treatment of neurosyphilisExpand
  • 117
  • 5
Critique of the Two-Fold Measure of Prediction Success for Ratios: Application for the Assessment of Drug-Drug Interactions
Current assessment of drug-drug interaction (DDI) prediction success is based on whether predictions fall within a two-fold range of the observed data. This strategy results in a potential biasExpand
  • 52
  • 5
A program for individual and population optimal design for univariate and multivariate response pharmacokinetic-pharmacodynamic models
The design of pharmacokinetic and pharmacodynamic experiments concerns a number of issues, among which are the number of observations and the times when they are taken. Often a model is used toExpand
  • 46
  • 5
Comparison of in-vivo and in-silico methods used for prediction of tissue: plasma partition coefficients in rat.
OBJECTIVES To use methods from the literature to predict rat tissue:plasma partition coefficients (Kps) and volume of distribution values. Determine which model provides the most accurate predictionsExpand
  • 37
  • 5
PBPK models for the prediction of in vivo performance of oral dosage forms.
Drug absorption from the gastrointestinal (GI) tract is a highly complex process dependent upon numerous factors including the physicochemical properties of the drug, characteristics of theExpand
  • 175
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