2,3-dinor-6-ketoprostaglandin F1alpha

Known as: Pgi2-M, 2,3-Dkpgf1alpha, Cyclopentanepentanoic Acid, 3,5-Dihydroxy-2-((1E,3S)-3-Hydroxy-1-Octenyl)-Gamma-Oxo-, (1R,2R,3R,5S)- 
A beta-oxidation product of 6-keto prostaglandin F1 alpha (PGF1a) and the major urinary metabolite of prostaglandin I2 (prostacyclin, PGI2). 2,3… (More)
National Institutes of Health

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Broader (1)

6-Ketoprostaglandin F1 alpha
analogs & derivatives

Papers overview

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2008
2008
Evaluation of VEGF-mediated signaling in primary human cells reveals a paracrine action for VEGF in osteoblast-mediated crosstalk to endothelial cells.
Communication between endothelial and bone cells is crucial for controlling vascular supply during bone growth, remodeling, and… (More)
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2005
2005
Hypertension increases the participation of vasoconstrictor prostanoids from cyclooxygenase-2 in phenylephrine responses.
OBJECTIVE The present study was designed to analyse whether hypertension alters the involvement of cyclooxygenase-2-derived… (More)
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2004
2004
Membrane-associated prostaglandin E synthase-1 is upregulated by proinflammatory cytokines in chondrocytes from patients with osteoarthritis
Prostaglandin E synthase (PGES) including isoenzymes of membrane-associated PGES (mPGES)-1, mPGES-2, and cytosolic PGES (cPGES… (More)
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Highly Cited
2002
Highly Cited
2002
Cyclooxygenase-2 promotes early atherosclerotic lesion formation in LDL receptor-deficient mice.
BACKGROUND Atherosclerosis has features of an inflammatory disease. Because cyclooxygenase (COX)-2 is expressed in… (More)
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Highly Cited
2002
Highly Cited
2002
Inducible nitric oxide synthase modulates cyclooxygenase-2 activity in the heart of conscious rabbits during the late phase of ischemic preconditioning.
Cyclooxygenase-2 (COX-2) is known to mediate the cardioprotective effects of the late phase of ischemic preconditioning (PC… (More)
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Highly Cited
1999
Highly Cited
1999
Elevated CSF prostaglandin E2 levels in patients with probable AD.
OBJECTIVE To determine CSF eicosanoid concentrations and brain cyclo-oxygenase activity in AD patients and age-matched control… (More)
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Highly Cited
1998
Highly Cited
1998
Upregulation of prostacyclin synthesis-related gene expression by shear stress in vascular endothelial cells.
Prostacyclin (prostaglandin I2, PGI2) has a variety of functions, including inhibition of smooth muscle cell proliferation… (More)
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1997
1997
Experimental fat embolism induces urine 2,3-dinor-6-ketoprostaglandin F1alpha and 11-dehydrothromboxane B2 excretion in pigs.
OBJECTIVE To evaluate the in vivo production of prostacyclin and thromboxane A2 during the initial phase of experimental fat… (More)
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Highly Cited
1997
Highly Cited
1997
Involvement of NF-kappaB in the regulation of cyclooxygenase-2 protein expression in LPS-stimulated J774 macrophages.
We investigated the involvement of NF-kappaB in the regulation of COX-2 protein expression and prostaglandin production in LPS… (More)
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Highly Cited
1996
Highly Cited
1996
Cyclooxygenase-1 and -2 of endothelial cells utilize exogenous or endogenous arachidonic acid for transcellular production of thromboxane.
The presence of prostaglandin (PG) H2 in the supernatant of human umbilical vein endothelial cells (HUVEC) stimulated by thrombin… (More)
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