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2,3-dinor-6-ketoprostaglandin F1alpha

Known as: Pgi2-M, 2,3-Dkpgf1alpha, Cyclopentanepentanoic Acid, 3,5-Dihydroxy-2-((1E,3S)-3-Hydroxy-1-Octenyl)-Gamma-Oxo-, (1R,2R,3R,5S)- 
A beta-oxidation product of 6-keto prostaglandin F1 alpha (PGF1a) and the major urinary metabolite of prostaglandin I2 (prostacyclin, PGI2). 2,3… Expand
National Institutes of Health

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2 relations

Broader (1)

6-Ketoprostaglandin F1 alpha
analogs & derivatives

Papers overview

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Highly Cited
2008
Highly Cited
2008
Evaluation of VEGF‐mediated signaling in primary human cells reveals a paracrine action for VEGF in osteoblast‐mediated crosstalk to endothelial cells
Communication between endothelial and bone cells is crucial for controlling vascular supply during bone growth, remodeling, and… Expand
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Highly Cited
2002
Highly Cited
2002
Cyclooxygenase-2 Promotes Early Atherosclerotic Lesion Formation in LDL Receptor–Deficient Mice
Background—Atherosclerosis has features of an inflammatory disease. Because cyclooxygenase (COX)-2 is expressed in… Expand
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Highly Cited
2002
Highly Cited
2002
Inducible Nitric Oxide Synthase Modulates Cyclooxygenase-2 Activity in the Heart of Conscious Rabbits During the Late Phase of Ischemic Preconditioning
Cyclooxygenase-2 (COX-2) is known to mediate the cardioprotective effects of the late phase of ischemic preconditioning (PC… Expand
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Highly Cited
1999
Highly Cited
1999
Elevated CSF prostaglandin E2 levels in patients with probable AD.
OBJECTIVE To determine CSF eicosanoid concentrations and brain cyclo-oxygenase activity in AD patients and age-matched control… Expand
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Highly Cited
1999
Highly Cited
1999
Acetaminophen inhibits spinal prostaglandin E2 release after peripheral noxious stimulation.
BACKGROUND Prostaglandin play a pivotal role in spinal nociceptive processing. At therapeutic concentrations, acetaminophen is… Expand
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Highly Cited
1998
Highly Cited
1998
Effects of inhibition of prostaglandin endoperoxide synthase‐2 in chronic gastro‐intestinal ulcer models in rats
1 In the stomach, prostaglandins protect the gastric mucosa against injuries. One rate‐limiting step in prostaglandin synthesis… Expand
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Highly Cited
1998
Highly Cited
1998
Upregulation of prostacyclin synthesis-related gene expression by shear stress in vascular endothelial cells.
Prostacyclin (prostaglandin I2, PGI2) has a variety of functions, including inhibition of smooth muscle cell proliferation… Expand
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Highly Cited
1997
Highly Cited
1997
Involvement of NF‐κB in the regulation of cyclooxygenase‐2 protein expression in LPS‐stimulated J774 macrophages
We investigated the involvement of NF‐κB in the regulation of COX‐2 protein expression and prostaglandin production in LPS… Expand
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Highly Cited
1997
Highly Cited
1997
Low-dose aspirin in prevention of miscarriage in women with unexplained or autoimmune related recurrent miscarriage: effect on prostacyclin and thromboxane A2 production.
Early pregnancies in women with a history of recurrent spontaneous abortion (RSA) are accompanied by a deficiency in vasodilatory… Expand
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Highly Cited
1976
Highly Cited
1976
The chemical structure of prostaglandin X (prostacyclin).
The chemical structure of prostaglandin X, the anti-aggregatory substance derived from prostaglandin endoperoxides, is 9-deoxy-6… Expand
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