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2,3-N-octanoylsphingosine

Known as: 2,3-N-octanoyl-D-erythro-trans-sphingosine, C8-ceramide 
National Institutes of Health

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2 relations

Broader (1)

Sphingosine
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Design, synthesis, and biological activity of a family of novel ceramide analogues in chemoresistant breast cancer cells.
Resistance to chemotherapy and endocrine therapy is a major cause of breast cancer treatment failure. We have synthesized six… 
Highly Cited
2007
Highly Cited
2007
Ceramide and glucosylceramide upregulate expression of the multidrug resistance gene MDR1 in cancer cells.
Highly Cited
2005
Highly Cited
2005
P-glycoprotein is implicated in the inhibition of ceramide-induced apoptosis in TF-1 acute myeloid leukemia cells by modulation of the glucosylceramide synthase pathway.
Highly Cited
2003
Highly Cited
2003
The role of neutral sphingomyelinase produced ceramide in lipopolysaccharide‐mediated expression of inducible nitric oxide synthase
Lipopolysaccharide (LPS) and interferon‐γ (IFN) treatment of C6 rat glioma cells increased the intracellular ceramide level and… 
Highly Cited
2002
Highly Cited
2002
Ceramide activates microglia to enhance the production/secretion of brain‐derived neurotrophic factor (BDNF) without induction of deleterious factors in vitro
In analyzing the regulation of neurotrophin production/secretion from microglia, C8‐ceramide (d‐erythro‐sphingosine, N‐octanoyl… 
Highly Cited
1997
Highly Cited
1997
Resistance to radiation-induced apoptosis in Burkitt's lymphoma cells is associated with defective ceramide signaling.
Increased sensitivity to ionizing radiation has been shown to be due to defects in double-strand break repair and mutations in… 
Highly Cited
1996
Highly Cited
1996
Sphingosine and its methylated derivative N,N‐dimethylsphingosine (DMS) induce apoptosis in a variety of human cancer cell lines
In the study of apoptosis initiated by various signals including ligands binding to cell membrane receptors such as Fas and TNFRI… 
Highly Cited
1996
Highly Cited
1996
Induction of apoptotic cell death in hen granulosa cells by ceramide.
Recent studies have demonstrated that ovarian follicle atresia occurs extensively before follicle selection into the avian… 
Highly Cited
1995
Highly Cited
1995
Short-chain ceramide-1-phosphates are novel stimulators of DNA synthesis and cell division: antagonism by cell-permeable ceramides.
Ceramide and ceramide-1-phosphate are sphingolipid analogues of diacylglycerol and phosphatidate, respectively, and they are… 
Highly Cited
1993
Highly Cited
1993
Tumor necrosis factor activation of the sphingomyelin pathway signals nuclear factor kappa B translocation in intact HL-60 cells.
Recent investigations suggest that tumor necrosis factor (TNF)-alpha may utilize the sphingomyelin pathway for signal… 
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