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17-(dimethylaminoethylamino)-17-demethoxygeldanamycin

Known as: 17-(dimethylaminoethylamino)-17-demethoxy-geldanamycin, 17-dimethylaminoethylamino-17-demethoxygeldanamycin, 17-dimethylaminoethylamino-17-demethoxy-geldanamycin 
An analogue of the antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin binds to HSP90, a chaperone protein that aids in the assembly… 
National Institutes of Health

Related topics

Related topics

8 relations
Alvespimycin HydrochlorideHSP90 Heat-Shock ProteinsNCIt Antineoplastic Agent TerminologySignal Transduction Inhibition

Broader (2)

BenzoquinonesLactams, Macrocyclic

Narrower (2)

KOS 1022NSC 707545

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Stabilization of mutant BRCA1 protein confers PARP inhibitor and platinum resistance
Significance Poly(ADP-ribose) polymerase (PARP) inhibitors have produced responses in homologous recombination (HR) repair… 
Review
2013
Review
2013
Targeting the molecular chaperone heat shock protein 90 (HSP90): lessons learned and future directions.
Highly Cited
2011
Highly Cited
2011
Hypoxia-Inducible Factor-1α–Dependent Protection from Intestinal Ischemia/Reperfusion Injury Involves Ecto-5′-Nucleotidase (CD73) and the A2B Adenosine Receptor
Intestinal ischemia/reperfusion injury (IR) is characterized by intermittent loss of perfusion to the gut, resulting in dramatic… 
Highly Cited
2010
Highly Cited
2010
Evidence that intrathecal morphine-3-glucuronide may cause pain enhancement via toll-like receptor 4/MD-2 and interleukin-1β
Highly Cited
2006
Highly Cited
2006
Benzoquinone ansamycin heat shock protein 90 inhibitors modulate multiple functions required for tumor angiogenesis
Heat shock protein 90 (Hsp90) is a molecular chaperone involved in maintaining the correct conformation and stability of its… 
Highly Cited
2005
Highly Cited
2005
Comparison of 17-dimethylaminoethylamino-17-demethoxy-geldanamycin (17DMAG) and 17-allylamino-17-demethoxygeldanamycin (17AAG) in vitro: effects on Hsp90 and client proteins in melanoma models
The heat shock protein Hsp90 is a potential target for drug discovery of novel anticancer agents. By affecting this protein… 
Highly Cited
2004
Highly Cited
2004
Simultaneous inhibition of hsp 90 and the proteasome promotes protein ubiquitination, causes endoplasmic reticulum-derived cytosolic vacuolization, and enhances antitumor activity.
The ansamycin antibiotic, geldanamycin, targets the hsp 90 protein chaperone and promotes ubiquitin-dependent proteasomal… 
Highly Cited
2004
Highly Cited
2004
Antiangiogenic Properties of 17-(Dimethylaminoethylamino)-17-Demethoxygeldanamycin
Purpose: The purpose of this study was to investigate the antiangiogenic properties of 17-(dimethylaminoethylamino)-17… 
Highly Cited
2004
Highly Cited
2004
Pharmacokinetics and pharmacodynamics of 17-demethoxy 17-[[(2-dimethylamino)ethyl]amino]geldanamycin (17DMAG, NSC 707545) in C.B-17 SCID mice bearing MDA-MB-231 human breast cancer xenografts
Purpose17-demethoxy 17-[[(2-dimethylamino)ethyl]amino]geldanamycin (17DMAG, NSC 707545) is a water-soluble analogue of 17… 
Highly Cited
2003
Highly Cited
2003
17AAG: low target binding affinity and potent cell activity--finding an explanation.
The ansamycin geldanamycin (GM) and its derivative, 17AAG, now in early clinical trials in cancer patients, have potent activity… 
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