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Alvespimycin Hydrochloride

Known as: 17-DMAG HCl, Geldanamycin,17-demethoxy-17-((2-(dimethylamino)ethyl)amino)-, Monohydrochloride 
The hydrochloride salt of alvespimycin, an analogue of the antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin binds to HSP90, a… 
National Institutes of Health

Related topics

Related topics

4 relations
17-(dimethylaminoethylamino)-17-demethoxygeldanamycinHSP90 Heat-Shock ProteinsKOS 1022Signal Transduction Inhibition

Papers overview

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2012
2012
Cancer Therapy : Clinical A Phase I Dose-Escalation Trial of Trastuzumab and Alvespimycin Hydrochloride ( KOS-1022 ; 17 DMAG ) in the Treatment of Advanced Solid Tumors
Purpose: We conducted a phase I dose-escalation study to define the maximum tolerated dose (MTD), pharmacokinetics (PK), and… 
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