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13-hydroxyoctadecadienoic acid

National Institutes of Health

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13-hydroxy-9,11-octadecadienoic acid

Papers overview

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Highly Cited
2010
Highly Cited
2010
Heat generates oxidized linoleic acid metabolites that activate TRPV1 and produce pain in rodents.
The transient receptor potential vanilloid 1 (TRPV1) channel is the principal detector of noxious heat in the peripheral nervous… Expand
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Highly Cited
2005
Highly Cited
2005
Melatonin-depleted blood from premenopausal women exposed to light at night stimulates growth of human breast cancer xenografts in nude rats.
The increased breast cancer risk in female night shift workers has been postulated to result from the suppression of pineal… Expand
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Review
2002
Review
2002
Melatonin as a chronobiotic/anticancer agent: cellular, biochemical, and molecular mechanisms of action and their implications for circadian-based cancer therapy.
Melatonin, as a new member of an expanding group of regulatory factors that control cell proliferation and loss, is the only… Expand
Review
2000
Review
2000
Metabolism of polyunsaturated fatty acids by skin epidermal enzymes: generation of antiinflammatory and antiproliferative metabolites.
In the skin epidermis, the metabolism of polyunsaturated fatty acids (PUFAs) is highly active. Dietary deficiency of linoleic… Expand
Highly Cited
1999
Highly Cited
1999
Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase.
The peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is a ligand-dependent nuclear receptor that has been implicated… Expand
Highly Cited
1999
Highly Cited
1999
Melatonin inhibition of cancer growth in vivo involves suppression of tumor fatty acid metabolism via melatonin receptor-mediated signal transduction events.
The growth of rat hepatoma 7288CTC in vivo is stimulated by the uptake of linoleic acid (LA) and its metabolism to 13… Expand
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Highly Cited
1992
Highly Cited
1992
Induction of interleukin 1 beta expression from human peripheral blood monocyte-derived macrophages by 9-hydroxyoctadecadienoic acid.
Oxidatively modified low density lipoproteins (LDL) have recently been proposed to play a role in atherogenesis by promoting foam… Expand
1991
1991
Metabolism of oxidized linoleic acid: characterization of 13-hydroxyoctadecadienoic acid dehydrogenase activity from rat colonic tissue.
An oxidized derivative of linoleic acid, 13-hydroxyoctadecadienoic acid (13-HODE), is dehydrogenated by an NAD+ dependent… Expand
Highly Cited
1990
Highly Cited
1990
Induction of epidermal hyperproliferation by topical n-3 polyunsaturated fatty acids on guinea pig skin linked to decreased levels of 13-hydroxyoctadecadienoic acid (13-hode).
Reversal of essential fatty acid deficiency (EFA) induced epidermal hyperproliferation was recently suggested to require linoleic… Expand
Highly Cited
1985
Highly Cited
1985
13-Hydroxyoctadecadienoic acid is the vessel wall chemorepellant factor, LOX.
We have previously reported that endothelial cells synthesize a cytosol-associated, lipoxygenase-derived metabolite, LOX, which… Expand
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