• Publications
  • Influence
Towards establishing dietary reference intakes for eicosapentaenoic and docosahexaenoic acids.
TLDR
The Technical Committee on Dietary Lipids of the International Life Sciences Institute North America sponsored a workshop to consider whether the body of evidence specific to the major chronic diseases in the United States--coronary heart disease, cancer, and cognitive decline--had evolved sufficiently to justify reconsideration of DRI for EPA+. Expand
Fatty acids in cardiovascular health and disease: a comprehensive update.
TLDR
There is some new evidence that is questioning the health benefits of even MUFAs and PUFAs, and in a few recent studies investigators have also failed to demonstrate expected cardiovascular benefits of marine-derived omega-3 fatty acids. Expand
Dietary stearidonic acid is a long chain (n-3) polyunsaturated fatty acid with potential health benefits.
  • J. Whelan
  • Biology, Medicine
  • The Journal of nutrition
  • 2009
TLDR
The comparative results suggest that SDA shares many of the biological effects of (n-3) LCPUFA and functions most similarly to dietary EPA compared with ALA when consumed in a typical Western diet, and could become a prominent surrogate for EPA in the commercial development of foods fortified with (n)-3) PUFA. Expand
Innovative dietary sources of n-3 fatty acids.
TLDR
N-3 PUFAs are being incorporated into nontraditional food sources because of advances in the technology to safely enrich/fortify the authors' food supply and because of newer technologies (microencapsulation and improved processing techniques that ensure stability and preserve the integrity of these unstable fatty acids. Expand
Adipose tissue stearoyl-CoA desaturase mRNA is increased by obesity and decreased by polyunsaturated fatty acids.
TLDR
It is concluded that obese Zucker rats overexpress the SCD gene in both liver and adipose tissue and PUFA directly suppress SCD expression in adipocytes, andSCD expression was directly downregulated in a dose dependent manner by PUFA in 3T3-L1 adipocytes. Expand
Effects of eicosapentaenoic and gamma-linolenic acid on lung permeability and alveolar macrophage eicosanoid synthesis in endotoxic rats.
TLDR
Lung permeability was greatest with corn oil and was significantly attenuated with 20% fish oil and 20%Fish oil and 5% borage oil, and this effect approached significance with 20%. Expand
Highly unsaturated (n-3) fatty acids, but not alpha-linolenic, conjugated linoleic or gamma-linolenic acids, reduce tumorigenesis in Apc(Min/+) mice.
TLDR
The results suggest that SDA and EPA attenuate tumorigenesis in this model and that this effect may be related in part to alterations in prostaglandin biosynthesis. Expand
Polycyclic Aromatic Compounds
Presence and Biotransformation of three Heteroaromatic Compounds Compared to an Aromatic Hydrocarbon J. Hellou , J. Leonard , J. Meade , S. Sharpe , J. Banoub , S. Papiernik , L. Eglinton & J. WhelanExpand
Highly Unsaturated (n-3) Fatty Acids, but Not α-Linolenic, Conjugated Linoleic or γ-Linolenic Acids, Reduce Tumorigenesis in ApcMin/+ Mice
TLDR
The results suggest that SDA and EPA attenuate tumorigenesis in this model and that this effect may be related in part to alterations in prostaglandin biosynthesis. Expand
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