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Inhibition of intestinal carcinogenesis in rats: effect of difluoromethylornithine with piroxicam or fish oil.
TLDR
Results show that a combination of a small amount of DFMO and piroxicam, each acting through a different mechanism, exerts an additive inhibitory effect on intestinal tumor formation in rats. Expand
Effect of dietary fiber on azoxymethane-induced intestinal carcinogenesis in rats.
TLDR
It is suggested that intestinal tumor frequency can be reduced by increased dietary fiber only when fat intake is not at a high level and the effect of fiber may be due to dilution of promoters and/or carcinogens in the intestinal tract. Expand
Modulation of prostaglandin H synthase activity by conjugated linoleic acid (CLA) and specific CLA isomers
TLDR
The results of this study demonstrate the potential of CLA and specific isomers of CLA to modulate prostaglandin biosynthesis and the efficacy differs for each isomer, with the 9(Z),11(E) CLA isomer being the most effective and the9(Z,11(Z) CLA has been the least effective inhibitor. Expand
Conjugation of the linoleic acid oxidation product, 13-oxooctadeca-9,11-dienoic acid, a bioactive endogenous substrate for mammalian glutathione transferase.
TLDR
The role of GST in the metabolic disposition of the bioactive oxidation products of linoleic acid has implications for the regulation of normal cellular functions by these versatile enzymes. Expand
Determination of malondialdehyde by ion-pairing high-performance liquid chromatography.
TLDR
The method has been applied to the quantitation of MDA production during microsomal lipid peroxidation and to an assessment of the stability of Mda in microsomesomal and urine samples. Expand
Metabolism of oxidized linoleic acid: characterization of 13-hydroxyoctadecadienoic acid dehydrogenase activity from rat colonic tissue.
TLDR
Characteristics of the reaction suggest this enzyme plays an important role in the response of the colonic mucosa to the mitogenic effect of oxidized fatty acids, and other characteristics suggest the enzyme is neither alcohol dehydrogenase, diol dehydrogen enzyme, nor a prostaglandin dehydrogenases. Expand
Activation of rat brain protein kinase C by lipid oxidation products.
TLDR
Since oxidation of unsaturated fatty acids to hydroperoxides is the first event in lipid peroxidation, activation of PKC by hydroperoxy fatty acids may be an early cellular response to oxidative stress. Expand
13-Oxo-ODE is an endogenous ligand for PPARγ in human colonic epithelial cells
TLDR
High amounts of 13-Oxo-ODE can be induced in CECs by stimulation of linoleic acid metabolism and binds to PPARγ and has anti-inflammatory effects. Expand
Combined inhibitors of carcinogenesis: effect on azoxymethane-induced intestinal cancer in rats.
TLDR
Results suggest that subpharmacologic doses of inhibitors, particularly those that inhibit the process by different mechanisms, while ineffective alone, may provide significant inhibition of tumorigenesis when used in combination. Expand
Production of 13-hydroxyoctadecadienoic acid (13-HODE) by prostate tumors and cell lines.
TLDR
The use of a polyclonal antibody specific for 13-(S)-HODE to detect this bioactive lipid for the first time in human prostate adenocarcinoma specimens (PCa) and the prostate cancer cell lines LNCaP and PC-3 by enzyme immunoassay provides a link between linoleic acid metabolism and the development or progression of prostate cancer. Expand
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