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10,11-methylenedioxycamptothecin

Known as: MDCPT cpd 
National Institutes of Health

Papers overview

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2004
2004
Camptothecin (CPT) analogs that form more stable ternary complexes with DNA and topoisomerase I (termed cleavable complexes) show… 
2001
2001
UCN-01 is a hydroxylated derivative of staurosporine and a potent protein kinase C (PKC) inhibitor. Interest in the potential… 
1996
1996
20(S)‐Camptothecin (CPT), a topoisomerase I inhibitor specifically toxic toward S‐phase cells, was tested topically for its… 
Highly Cited
1995
Highly Cited
1995
Camptothecins belong to a group of anticancer agents with a specific mechanism of action: stabilization and trapping of… 
Highly Cited
1993
Highly Cited
1993
The cytotoxic alkaloid camptothecin (CPT) and several of its analogues, including the clinically relevant topotecan (TPT… 
1991
1991
Previous studies in rapidly proliferating rodent cells have suggested that the lethal effect of the DNA topoisomerase I inhibitor… 
1990
1990
We had previously shown that 10,11-methylenedioxy-20-(RS)-camptothecin (MDO-CPT) is a more potent inhibitor of purified DNA…