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Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia.
Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis
As a result of bioassay–guided fractionation, betulinic acid, a pentacyclic triterpene, was identified as a melanoma–specific cytotoxic agent and antitumour activity was mediated by the induction of apoptosis.
Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata1,2
Complete isolation and characterization of silybins and isosilybins from milk thistle (Silybum marianum).
- Nam-Cheol Kim, T. Graf, C. Sparacino, M. Wani, M. Wall
- Chemistry, MedicineOrganic & biomolecular chemistry
- 15 May 2003
Complete separation, isolation, and structural characterization of four diastereoisomeric flavonolignans from the seeds of milk thistle were achieved for the first time using a preparative reversed-phase HPLC method.
Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: evidence for a specific receptor site and a relation to antitumor activity.
Stereochemistry and the positions of substituents were found to be crucial for the presence or absence of effects on topoisomerase I, indicating that the compounds interact with an asymmetrical receptor site on the enzyme or enzyme-DNA complex.
Camptothecin and taxol: discovery to clinic--thirteenth Bruce F. Cain Memorial Award Lecture.
Camptothecin and analogues singly or combined with cisplatin show efficacy against solid tumors, breast, lung, and colorectal, which hitherto have been unaffected by most cancer chemotherapeutic agents.
Camptothecin and taxol: from discovery to clinic.
DNA topoisomerase I-mediated DNA cleavage and cytotoxicity of camptothecin analogues.
The study shows that the drug-induced accumulation of enzyme-DNA cleavable complexes is directly proportional to drug cytotoxicity and antitumor activity.
Milk thistle and prostate cancer: differential effects of pure flavonolignans from Silybum marianum on antiproliferative end points in human prostate carcinoma cells.
Silymarin and silibinin were shown for the first time to suppress the activity of the DNA topoisomerase IIalpha gene promoter in DU145 cells and, among the pure compounds, isosilybin B was again the most effective.
Lipid bilayer partitioning and stability of camptothecin drugs.
Iodide quenching data indicate that membrane-bound camptothecin intercalates between the lipid acyl chains, in a protected environment well removed from the aqueous interface.