• Publications
  • Influence
Increased class 3 semaphorin expression modulates the invasive and adhesive properties of prostate cancer cells.
The class 3 semaphorins, sema3A and sema3C, provide important guidance cues in cell development and in cancer; however, the role of these semaphorins in prostate cancer is not known. We report hereExpand
  • 108
  • 6
  • PDF
Resveratrol is rapidly metabolized in athymic (nu/nu) mice and does not inhibit human melanoma xenograft tumor growth.
Resveratrol has been shown to have anticarcinogenic activity. We previously found that resveratrol inhibited growth and induced apoptosis in 2 human melanoma cell lines. In this study we determinedExpand
  • 91
  • 5
  • PDF
Cleavage of 14-3-3 Protein by Caspase-3 Facilitates Bad Interaction with Bcl-x(L) during Apoptosis*
The 14-3-3ϵ protein was identified as one of the caspase-3 substrates by the modified yeast two-hybrid system. The cellular 14-3-3ϵ protein was also cleaved in response to the treatment of apoptosisExpand
  • 85
  • 4
PPAR-gamma ligands and amino acid deprivation promote apoptosis of melanoma, prostate, and breast cancer cells.
The PPAR-gamma ligands, 15-deoxy-Delta(12,14)-prostaglandin J(2) and ciglitazone, and the PPAR-alpha ligand, WY-14643, were examined for their effects on proliferation and apoptosis of A375 melanoma,Expand
  • 29
  • 4
Resveratrol is a potent inducer of apoptosis in human melanoma cells.
Resveratrol is a plant polyphenol found in grapes and red wine. It has been found to have beneficial effects on the cardiovascular system. Resveratrol also inhibits the growth of various tumor cellExpand
  • 138
  • 3
  • PDF
Chronic alcohol consumption in mice increases the proportion of peripheral memory T cells by homeostatic proliferation
This study examined the mechanism underlying the increase of peripheral memory phenotype T cells that occurs during chronic alcohol consumption in mice. Female C57BL/6 mice were given 20% (w/v)Expand
  • 50
  • 3
Specific Amino Acid Dependency Regulates Invasiveness and Viability of Androgen-Independent Prostate Cancer Cells
Androgen-independent prostate cancer is resistant to therapy and is often metastatic. Here we studied the effect of deprivation of tyrosine and phenylalanine (Tyr/Phe), glutamine (Gln), or methionineExpand
  • 44
  • 3
A role for NF-kappa B activation in perforin expression of NK cells upon IL-2 receptor signaling.
Optimal NK cell development and activation as well as cytolytic activity involves IL-2R beta signals that also up-regulate expression of the pore-forming effector molecule perforin. Although theExpand
  • 46
  • 3
Ethanol induces marked changes in lymphocyte populations and natural killer cell activity in mice.
Treatment of mice in vivo with 5% w/v ethanol given in a liquid diet causes marked changes in spleen, peripheral blood, and thymus lymphocytes. In both the thymus and spleen, there is an acuteExpand
  • 59
  • 2
Laboratory models available to study alcohol-induced organ damage and immune variations: choosing the appropriate model.
The morbidity and mortality resulting from alcohol-related diseases globally impose a substantive cost to society. To minimize the financial burden on society and improve the quality of life forExpand
  • 66
  • 2