FAQ

1,2-diacylglycerol

Known as: Diacylglycerol, DAG, DIGLYCERIDE 
A synthetic oil with anti-obesity activity. The enzymatically synthesized isoform, 1,3-isoform diacylglycerol, is suggested to decrease formation of… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1948-2017
05010015019482016

Related topics

Related topics

5 relations
DAG1 genesecond messenger

Broader (3)

DiglyceridesGlyceridesSecond Messenger Systems

Related mentions per year

Related mentions per year

1938-2018
19401960198020002020
1,2-diacylglycerol
Glycerides
Diglycerides
Second Messenger Systems
DAG1 gene
second messenger

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2002
Highly Cited
2002
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle.
Recent studies have demonstrated that fatty acids induce insulin resistance in skeletal muscle by blocking insulin activation of… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 5
  • figure 4
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Hormone-sensitive lipase deficiency in mice causes diglyceride accumulation in adipose tissue, muscle, and testis.
Hormone-sensitive lipase (HSL) is expressed predominantly in white and brown adipose tissue where it is believed to play a… (More)
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members.
Studies involving the cloning and disruption of the gene for acyl-CoA:diacylglycerol acyltransferase (DGAT) have shown that… (More)
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Defective uptake and utilization of long chain fatty acids in muscle and adipose tissues of CD36 knockout mice.
The transmembrane protein CD36 has been identified in isolated cell studies as a putative transporter of long chain fatty acids… (More)
Is this relevant?
Highly Cited
1998
Highly Cited
1998
Green Fluorescent Protein (GFP)-tagged Cysteine-rich Domains from Protein Kinase C as Fluorescent Indicators for Diacylglycerol Signaling in Living Cells
Cysteine-rich domains (Cys-domains) are approximately 50-amino acid-long protein domains that complex two zinc ions and include a… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • table I
Is this relevant?
Highly Cited
1998
Highly Cited
1998
Protein Kinase C as a Molecular Machine for Decoding Calcium and Diacylglycerol Signals
The specificity of many signal transduction pathways relies on the temporal coordination of different second messenger signals… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1998
Highly Cited
1998
RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs.
RasGRP, a guanyl nucleotide-releasing protein for the small guanosine triphosphatase Ras, was characterized. Besides the… (More)
Is this relevant?
Highly Cited
1992
Highly Cited
1992
Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell…
In the present study, we have measured protein kinase C (PKC) specific activities and total diacylglycerol (DAG) level in the… (More)
Is this relevant?
Highly Cited
1990
Highly Cited
1990
1,2-Diacylglycerol and ceramide levels in insulin-resistant tissues of the rat in vivo.
Phorbol esters have been reported to decrease sensitivity or responsiveness to insulin in cells in vitro. Since phorbol esters… (More)
Is this relevant?
Highly Cited
1986
Highly Cited
1986
Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells.
A simple enzymatic method for the quantitation of the mass of sn-1,2-diacylglycerol (DAG) present in crude lipid extracts was… (More)
Is this relevant?