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Inhibition of fatty acid synthesis by the antibiotic cerulenin. Specific inactivation of beta-ketoacyl-acyl carrier protein synthetase.
- G. D'agnolo, I. Rosenfeld, J. Awaya, S. O̅mura, P. Vagelos
- Biology, Medicine
- Biochimica et biophysica acta
- 29 November 1973
Abstract Cerulenin, (2S) (3R)2,3-epoxy-4-oxo-7,10-dodecadienoylamide, an antibiotic isolated from the culture filtrate of Cephalosporium caerulens, inhibits the fatty acid synthetase of Escherichia… Expand
The specificity of triglyceride synthesis from diglycerides in chicken adipose tissue.
The evidence presently available indicates that the final step in the synthesis of triglycerides in liver is the esterification of an Q: ,/3-diglyceride by an activated fatty acid (I, 2). Weiss,… Expand
Studies on the mechnism of activation of acetyl coenzyme A carboxylase by citrate.
Saturated fatty acid biosynthesis and its regulation.
Acetyl CoA carboxylase. I. Requirement for two protein fractions.
The polypeptide composition of intra-axonally transported proteins: evidence for four transport velocities.
- M. Willard, W. Cowan, P. Vagelos
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences…
- 1 June 1974
Using a method of gradient gel electrophoresis coupled with autoradiography, we have analyzed the polypeptide composition of the proteins being transported down the axons of the projecting neurons of… Expand
The mechanism of tricarboxylic acid cycle regulation of fatty acid synthesis.
Reaction 1, the carboxylation of acety-CoA to form malonylCo& is catalyzed by acetyl-CoA carboxylase, a biotin enzyme (l-6). Reaction 2, the reaction of acetyl-CoA with 7 moles of malonyl-CoA and 14… Expand
Effect of dietary linoleate on synthesis and degradation of fatty acid synthetase from rat liver.
The induction of fatty acid synthetase activity in rat liver is markedly reduced by feeding a diet containing a source of linoleate. Within 48 h after changing from a fat-free, high carbohydrate diet… Expand
Role of adenylate kinase in the regulation of macromolecular biosynthesis in a putative mutant of Escherichia coli defective in membrane phospholipid biosynthesis.
The regulation of macromolecular biosynthesis was studied in a temperature-sensitive mutant of Escherichia coli previously identified as containing a single mutation causing a thermolabile… Expand