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(carbonyl-11C)desmethyl-WAY-100635

National Institutes of Health

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desmethyl-WAY 100635

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Highly Cited
2006
Highly Cited
2006
Synthesis and biologic evaluation of a novel serotonin 5-HT1A receptor radioligand, 18F-labeled mefway, in rodents and imaging by PET in a nonhuman primate.
UNLABELLED Serotonin 5-HT1A receptors have been implicated in disorders of the central nervous system and, therefore, are being… 
2003
2003
Effects of 8-OH-DPAT and WAY-100635 on performance on a time-constrained progressive-ratio schedule
RationalePerformance on progressive-ratio schedules has been proposed as a means of assessing the effects of drugs on motivation… 
Highly Cited
2002
Highly Cited
2002
Effects of intra-hippocampal infusion of WAY-100635 on plus-maze behavior in mice Influence of site of injection and prior test experience
2002
2002
Anxiolytic-like effect of way-100635 microinfusions into the median (but not dorsal) raphe nucleus in mice exposed to the plus-maze: influence of prior test experience
2002
2002
The PET radioligand [carbonyl-(11)C]desmethyl-WAY-100635 binds to 5-HT(1A) receptors and provides a higher radioactive signal than [carbonyl-(11)C]WAY-100635 in the human brain.
UNLABELLED 5-Hydroxytryptamine (serotonin)-1A (5-HT(1A)) receptors are of key interest in research on the pathophysiology and… 
Highly Cited
1998
Highly Cited
1998
[carbonyl-11C]Desmethyl-WAY-100635 (DWAY) is a potent and selective radioligand for central 5-HT1A receptors in vitro and in vivo
Abstract. [carbonyl-11C]Desmethyl-WAY-100635 (DWAY) is possibly a low-level metabolite appearing in plasma after intravenous… 
Highly Cited
1998
Highly Cited
1998
Quantitative analyses of carbonyl-carbon-11-WAY-100635 binding to central 5-hydroxytryptamine-1A receptors in man.
UNLABELLED The serotonin 5-hydroxytryptamine-1A (5-HT1A) receptor subtype is of central interest in research on the… 
Highly Cited
1998
Highly Cited
1998
Characterisation of the appearance of radioactive metabolites in monkey and human plasma from the 5-HT1A receptor radioligand, [carbonyl-11C]WAY-100635--explanation of high signal contrast in PET and…
Highly Cited
1996
Highly Cited
1996
WAY-100635, a potent and selective 5-hydroxytryptamine1A antagonist, increases serotonergic neuronal activity in behaving cats: comparison with (S)-WAY-100135.
We reported previously that pharmacological blockade of somatodendritic 5-hydroxytryptamine (5-HT)1A autoreceptors with spiperone… 
Highly Cited
1996
Highly Cited
1996
Exquisite delineation of 5-HT1A receptors in human brain with PET and [carbonyl-11 C]WAY-100635.
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