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Positron emission tomographic analysis of central D1 and D2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Relation to extrapyramidal side effects.
- L. Farde, A. Nordström, F. Wiesel, S. Pauli, C. Halldin, G. Sedvall
- Psychology, MedicineArchives of General Psychiatry
- 1 July 1992
This finding indicates that neuroleptic-induced extrapyramidal syndromes are related to the degree of central D2 occupancy induced in the basal ganglia of drug-treated schizophrenic patients and demonstrates that clozapine is also "atypical" with respect to the central D1 occupancy in patients.
Polymorphisms in the dopamine D2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers
The results suggest that DRD2 genotypes may participate differentially in the regulation of striatal dopamine D2 receptor density in healthy human subjects.
The correlative triad among aging, dopamine, and cognition: Current status and future prospects
A PET study of
- L. Farde, N. Ginovart, C. Halldin, Y. Chou, H. Olsson, C. Swahn
- Biology, PsychologyInternational Journal of Neuropsychopharmacology
The results support the view that [11C]ß-CIT-FE is a suitable radioligand for clinical studies of the dopamine transporter, in particular for studies requiring short data acquisition or repeated PET measurements on the same day.
Age-related cognitive deficits mediated by changes in the striatal dopamine system.
D(2) receptor binding is a more important factor than chronological age in accounting for variation in cognitive performance across the adult lifespan, and changes in dopamine neurotransmission play an important role in aging-related cognitive decline.
Kinetic Analysis of Central [11C]Raclopride Binding to D2-Dopamine Receptors Studied by PET—A Comparison to the Equilibrium Analysis
- L. Farde, L. Eriksson, G. Blomquist, C. Halldin
- Biology, ChemistryJournal of Cerebral Blood Flow and Metabolism
- 1 October 1989
Examination of [11C]raclopride uptake in brain regions devoid of specific D2-dopamine receptor binding indicated a fourth compartment in which uptake was reversible, nonstereoselective, and nonsaturable in the dose range studied.
Changes in Cortical Dopamine D1 Receptor Binding Associated with Cognitive Training
It is shown that the training of working memory, which improves working memory capacity, is associated with changes in the density of cortical dopamine D1 receptors, which demonstrates a reciprocal interplay between mental activity and brain biochemistry in vivo.
Central D2-dopamine receptor occupancy in relation to antipsychotic drug effects: A double-blind PET study of schizophrenic patients
Distribution of D1- and D2-Dopamine Receptors, and Dopamine and Its Metabolites in the Human Brain
- H. Hall, G. Sedvall, O. Magnusson, J. Kopp, C. Halldin, L. Farde
- Biology, MedicineNeuropsychopharmacology
- 1 December 1994
Both dopamine receptor subtypes, as well as dopamine, HVA and DOPAC, were primarily found in the basal ganglia, and the receptor distribution in the autoradiographic study was consistent with that demonstrated in the living human brain using [11C].