Mechanisms of interorgan crosstalk in health and disease

@article{Herrlich2022MechanismsOI,
  title={Mechanisms of interorgan crosstalk in health and disease},
  author={Andreas Herrlich and Eirini Kefaloyianni and Stefan Rose-John},
  journal={FEBS Letters},
  year={2022},
  volume={596},
  url={https://api.semanticscholar.org/CorpusID:247438700}
}
The development of multicellularity of organisms during evolution brought about the need for coordinated activity of different cell types and organs in order to adapt to changing external and internal microenvironmental conditions and the role that interorgan communication plays in this process is reviewed.
7 Citations

Erythrocyte Extracellular Vesicles Amalgamate into the Hair and Skin to Maintain Homeostasis

A previously unknown role of erythrocytes in amalgamating into hair structures is identified and a new therapeutic approach using erythrocyte EVs to promote hair regeneration in AGA patients is revealed.

A time-resolved multi-omics atlas of transcriptional regulation in response to high-altitude hypoxia across whole-body tissues

P phenotypic and transcriptional evidence indicate that antenatal hypoxia could improve hypoxia tolerance in offspring, and time-series expression data of candidate genes associated with human mountain sickness and high-altitude adaptation are provided.

Inflammation and gut dysbiosis as drivers of CKD–MBD

The role of alterations in the gut microbial ecosystem, as well as inflammation and oxidative stress, in the bone and mineral disorder that affects patients with chronic kidney disease is examined and novel therapeutic options that can target these disease factors are explored.

Latent inter-organ mechanism of idiopathic pulmonary fibrosis unveiled by a generative computational approach

A generative computational framework for machine-mediated synthesis of mechanisms that facilitates and complements the traditional experimental approaches in biomedical sciences is employed to identify a putative molecular crosstalk system across the lung and the liver of Idiopathic pulmonary fibrosis.

A prospective observational study to correlate lung ultrasound with clinical severity and prognosis score in patients with primary pulmonary pathology on invasive ventilatory support

Background: Lung ultrasound (LUS) is a known imaging modality employed for monitoring patients in an intensive care unit. This study evaluates, LUS in assessing disease severity and prognosis, by

Inter-organ communication in the regulation of lipid metabolism: focusing on the network between the liver, intestine, and heart.

This review discusses how lipid metabolism is regulated by the inter-organ communication, focusing on the network axis between the liver, intestine, and heart.

Immunologic and endocrine functions of adipose tissue: implications for kidney disease

The mechanistic basis of this interorgan crosstalk between various adipose depots and other organs, which clearly has great therapeutic potential given the increasing rates of chronic kidney disease secondary to obesity and type 2 diabetes mellitus, is discussed.

Heart development and regeneration—a multi‐organ effort

An overview of inter‐organ signals that take part in development and regeneration of the heart is provided and the potential of inter-organ modulatory approaches for possible therapeutic use is discussed.

Neuroimmune circuits in inter-organ communication

The impact of bidirectional neuroimmune interactions in tissue biology, organ physiology and embryonic development is focused on and how this fast-evolving field is redefining the tenets of inter-organ and intergenerational communications is explored.

Adipose Extracellular Vesicles in Intercellular and Inter-Organ Crosstalk in Metabolic Health and Diseases

The latest clinical evidence supporting aberrant production and/or function of ADevs as a contributor to obesity-related chronic inflammation and metabolic complications is highlighted and the opportunities and challenges in developing novel therapies by targeting ADEVs are discussed.

Multiorgan microphysiological systems as tools to interrogate interorgan crosstalk and complex diseases

The current state of modeling multiorgan physiology is discussed and current opportunities and challenges are evaluated to identify novel relationships between interorgan crosstalk, metabolism, and immunity.

Muscle–Organ Crosstalk: The Emerging Roles of Myokines

It is suggested that myokines may be useful biomarkers for monitoring exercise prescription for people with, for example, cancer, diabetes, or neurodegenerative diseases.

Fibroblast‐mediated intercellular crosstalk in the healthy and diseased heart

The current knowledge of fibroblast interactions in the healthy, diseased, and aging heart is reviewed and interactions that fibroblasts establish with other cells of the heart, specifically cardiomyocytes, endothelial cells and immune cells, and particularly those relying on paracrine, electrical, and exosomal communication modes are reviewed.

Batokines: Mediators of Inter-Tissue Communication (a Mini-Review)

This review highlights aspects of brown adipose tissue (BAT) communication with other organ systems and how BAT-to-tissue cross-talk could help elucidate future obesity treatments.

Extracellular Vesicles in Viral Infections of the Nervous System

The interactions between EV biogenesis and the release of virus particles are described while also reviewing the role of EVs in various viral infections, such as HIV-1, HTLV, Zika, CMV, EBV, Hepatitis B and C, JCV, and HSV-1.