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A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes (*)
We describe a novel 30-kDa secretory protein, Acrp30 (adipocyte complement-related protein of 30 kDa), that is made exclusively in adipocytes and whose mRNA is induced over 100-fold during adipocyte…
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Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis
TLDR
It is shown that acute exercise induces autophagy in skeletal and cardiac muscle of fed mice and BCL2 is a crucial regulator of exercise- (and starvation)-induced autophagic induction in vivo, which may contribute to the beneficial metabolic effects of exercise.
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Adipose tissue remodeling and obesity.
TLDR
There are remarkable similarities between adipose expansion and growth of solid tumors, a phenomenon that presents both an opportunity and a challenge, since pharmacological interventions supporting healthy adipose tissue adaptation can also facilitate tumor growth.
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The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
TLDR
It is proposed that Acrp30 is a potent insulin enhancer linking adipose tissue and whole-body glucose metabolism, which triggers a transient decrease in basal glucose levels in mice treated with streptozotocin.
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Caveolins, a Family of Scaffolding Proteins for Organizing “Preassembled Signaling Complexes” at the Plasma Membrane*
TLDR
Because the responsibilities assigned to caveolae continue to increase, this review will focus on: (i) caveolin structure/function and (ii) Caveolae-associated signal transduction.
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Adipose tissue, inflammation, and cardiovascular disease.
TLDR
The targeted suppression of various proinflammatory cascades in adipocytes specifically represents an exciting new therapeutic opportunity for the cardiovascular disease area.
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Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin
TLDR
Observations suggest a unifying mechanism of action for the beneficial systemic effects exerted by adiponectin, with sphingolipid metabolism as its core upstream signaling component.
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Expression cloning of SR-BI, a CD36-related class B scavenger receptor.
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Caveolins, Liquid-Ordered Domains, and Signal Transduction
TLDR
This review seeks to update the working definition of caveolae, describe the functional roles of the caveolin gene family, and summarize the evidence that supports a role for Caveolae as mediators of a number of cellular signaling processes.
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Tracking adipogenesis during white adipose tissue development, expansion and regeneration
TLDR
The developed system for the inducible, permanent labeling of mature adipocytes that is called the AdipoChaser mouse and results highlight the extensive differences in adipogenic potential in various fat depots.
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