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A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes (*)
We describe a novel 30-kDa secretory protein, Acrp30 (adipocyte complement-related protein of 30 kDa), that is made exclusively in adipocytes and whose mRNA is induced over 100-fold during adipocyteExpand
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The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
Acrp30 is a circulating protein synthesized in adipose tissue. A single injection in mice of purified recombinant Acrp30 leads to a 2–3-fold elevation in circulating Acrp30 levels, which triggers aExpand
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Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis
Exercise has beneficial effects on human health, including protection against metabolic disorders such as diabetes. However, the cellular mechanisms underlying these effects are incompletelyExpand
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Caveolins, a Family of Scaffolding Proteins for Organizing “Preassembled Signaling Complexes” at the Plasma Membrane*
Caveolae are vesicular invaginations of the plasma membrane. The chief structural proteins of caveolae are the caveolins. Caveolins form a scaffold onto which many classes of signaling molecules canExpand
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Caveolins, Liquid-Ordered Domains, and Signal Transduction
Caveolae were originally identified as flask-shaped invaginations of the plasma membrane in endothelial and epithelial cells (14). Prior to the development of biochemical methods for theirExpand
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Tracking adipogenesis during white adipose tissue development, expansion and regeneration
White adipose tissue displays high plasticity. We developed a system for the inducible, permanent labeling of mature adipocytes that we called the AdipoChaser mouse. We monitored adipogenesis duringExpand
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Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin
The adipocyte-derived secretory factor adiponectin promotes insulin sensitivity, decreases inflammation and promotes cell survival. No unifying mechanism has yet explained how adiponectin can exertExpand
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Expression cloning of SR-BI, a CD36-related class B scavenger receptor.
Scavenger receptors are integral membrane proteins that mediate the endocytosis of modified lipoproteins. The first of these to be purified and cloned were the type I and II macrophage scavengerExpand
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Characterization of caveolin-rich membrane domains isolated from an endothelial-rich source: implications for human disease
Caveolae are 50-100-nm membrane microdomains that represent a subcompartment of the plasma membrane. Previous morphological studies have implicated caveolae in (a) the transcytosis of macromoleculesExpand
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Structure-Function Studies of the Adipocyte-secreted Hormone Acrp30/Adiponectin
Acrp30/adiponectin is an adipocyte-specific secretory protein that has recently been implicated as a mediator of systemic insulin sensitivity with liver and muscle as target organs. Acrp30 is foundExpand
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