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Estrogen deficiency and bone loss: an inflammatory tale.
Estrogen plays a fundamental role in skeletal growth and bone homeostasis in both men and women. Although remarkable progress has been made in our understanding of how estrogen deficiency causes boneExpand
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Estrogen, cytokines, and pathogenesis of postmenopausal osteoporosis
  • R. Pacifici
  • Medicine
  • Journal of bone and mineral research : the…
  • 1 August 1996
In summary, available data demonstrate that IL-1 and TNF are the causative agents underlying the bone loss induced by estrogen deficiency. Indeed, these factors are produced in bone and the boneExpand
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Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-alpha.
Estrogen deficiency induces bone loss by upregulating osteoclastogenesis by mechanisms not completely defined. We found that ovariectomy-enhanced T-cell production of TNF-alpha, which, acting throughExpand
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Marked decrease in plasma antioxidants in aged osteoporotic women: results of a cross-sectional study.
Although recent epidemiological studies found a positive correlation between dietary vitamin C intake and bone mineral density, data on plasma levels of vitamin C or other antioxidants inExpand
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Interleukin-7 stimulates osteoclast formation by up-regulating the T-cell production of soluble osteoclastogenic cytokines.
In unstimulated conditions osteoclast renewal occurs as a result of the stromal cell production of the key osteoclastogenic factors, receptor activator of NFkB ligand (RANKL) and macrophageExpand
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IFN-gamma stimulates osteoclast formation and bone loss in vivo via antigen-driven T cell activation.
T cell-produced cytokines play a pivotal role in the bone loss caused by inflammation, infection, and estrogen deficiency. IFN-gamma is a major product of activated T helper cells that can functionExpand
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Sex steroid deficiency-associated bone loss is microbiota dependent and prevented by probiotics.
A eubiotic microbiota influences many physiological processes in the metazoan host, including development and intestinal homeostasis. Here, we have shown that the intestinal microbiota modulatesExpand
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Up-regulation of TNF-producing T cells in the bone marrow: A key mechanism by which estrogen deficiency induces bone loss in vivo
In vivo studies have shown T cells to be central to the mechanism by which estrogen deficiency induces bone loss, but the mechanism involved remains, in part, undefined. In vitro, T cells fromExpand
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T lymphocytes amplify the anabolic activity of parathyroid hormone through Wnt10b signaling.
Intermittent administration of parathyroid hormone (iPTH) is used to treat osteoporosis because it improves bone architecture and strength, but the underlying cellular and molecular mechanisms areExpand
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Effect of surgical menopause and estrogen replacement on cytokine release from human blood mononuclear cells.
To determine whether mononuclear cell secretory products contribute to the changes in bone turnover that characterize the development of postmenopausal osteoporosis, we evaluated the effects ofExpand
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