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The anti-inflammatory effect of exercise.
Regular exercise offers protection against all-cause mortality, primarily by protection against cardiovascular disease and Type 2 diabetes mellitus. The latter disorders have been associated withExpand
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Muscle as an endocrine organ: focus on muscle-derived interleukin-6.
Skeletal muscle has recently been identified as an endocrine organ. It has, therefore, been suggested that cytokines and other peptides that are produced, expressed, and released by muscle fibers andExpand
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IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans.
The purpose of the present study was to test the hypothesis that a transient increase in plasma IL-6 induces an anti-inflammatory environment in humans. Therefore, young healthy volunteers received aExpand
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Exercise and the immune system: regulation, integration, and adaptation.
Stress-induced immunological reactions to exercise have stimulated much research into stress immunology and neuroimmunology. It is suggested that exercise can be employed as a model of temporaryExpand
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Pro‐ and anti‐inflammatory cytokine balance in strenuous exercise in humans
1 The present study investigates to what extent and by which time course prolonged strenuous exercise influences the plasma concentration of pro‐inflammatory and inflammation responsive cytokines asExpand
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Muscle‐derived interleukin‐6: mechanisms for activation and possible biological roles
It has recently been demonstrated that the marked increase in the systemic concentration of cytokine interleukin‐6 (IL‐6) seen with exercise originates from the contracting limb and that skeletalExpand
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Evidence for a release of brain‐derived neurotrophic factor from the brain during exercise
Brain‐derived neurotrophic factor (BDNF) has an important role in regulating maintenance, growth and survival of neurons. However, the main source of circulating BDNF in response to exercise isExpand
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Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase
Although interleukin-6 (IL-6) has been associated with insulin resistance, little is known regarding the effects of IL-6 on insulin sensitivity in humans in vivo. Here, we show that IL-6 infusionExpand
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Evidence for prescribing exercise as therapy in chronic disease
Considerable knowledge has accumulated in recent decades concerning the significance of physical activity in the treatment of a number of diseases, including diseases that do not primarily manifestExpand
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Evidence that interleukin‐6 is produced in human skeletal muscle during prolonged running
1 This study was performed to test the hypothesis that inflammatory cytokines are produced in skeletal muscle in response to prolonged intense exercise. Muscle biopsies and blood samples wereExpand
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