Longitudinal evaluation of dehydroepiandrosterone (DHEA), its sulfated form and estradiol with cancer-related cognitive impairment in early-stage breast cancer patients receiving chemotherapy

@article{Toh2022LongitudinalEO,
  title={Longitudinal evaluation of dehydroepiandrosterone (DHEA), its sulfated form and estradiol with cancer-related cognitive impairment in early-stage breast cancer patients receiving chemotherapy},
  author={Yi Long Toh and Chia Jie Tan and Ning Yi Yap and Ritesh Parajuli and Aik Jiang Lau and Alexandre Chan},
  journal={Scientific Reports},
  year={2022},
  volume={12},
  url={https://api.semanticscholar.org/CorpusID:252685518}
}
There was an association between magnitude of change in biomarker levels with self-reported CRCI which suggests that the hormonal pathway related to DHEAS may be implicated in acute CRCI for breast cancer survivors.
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The association between anxiety and DHEA remained positive in advanced cancer stages and chemotherapy patients, and three factors, including DHEA, PTSSs, and fatigue, were observed.

43 References

Prechemotherapy Levels of Plasma Dehydroepiandrosterone and Its Sulfated Form as Predictors of Cancer‐Related Cognitive Impairment in Patients with Breast Cancer Receiving Chemotherapy

The objective of this study was to evaluate whether an association exists between prechemotherapy plasma DHEA(S) levels and onset of CRCI in patients with breast cancer receiving chemotherapy.

Association between dehydroepiandrosterone-sulfate and attention in long-term survivors of childhood acute lymphoblastic leukemia treated with only chemotherapy

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This study supports the need for further investigations of the sex-specific effects of DHEAS on cognition and its underlying mechanisms of action and examined three potential mechanisms of D HEAS action--sex hormone sufficiency, inflammatory status, and glucose regulation.

Administration of dehydroepiandrosterone (DHEA) increases serum levels of androgens and estrogens but does not enhance short-term memory in post-menopausal women

Dehydroepiandrosterone, Its Sulfate and Cognitive Functions

A positive correlation between DHEA-S blood levels and global cognition was found in women and men, and the D HEA effect on cognition is limited to one study conducted among young men with high-doses.

Evidence that androgenic and estrogenic metabolites contribute to the effects of dehydroepiandrosterone on cognition in postmenopausal women

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