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DHEA and DHEA‐S: A Review
- P. Kroboth, F. Salek, A. Pittenger, T. Fabian, R. Frye
- Medicine, BiologyJournal of clinical pharmacology
- 1 April 1999
DHEA and DHEA‐S concentrations as they relate to stress, central nervous system function and psychiatric disorders, insulin sensitivity, immunological function, and cardiovascular disorders are addressed.
Liver disease selectively modulates cytochrome P450–mediated metabolism
Validation of the five‐drug “Pittsburgh cocktail” approach for assessment of selective regulation of drug‐metabolizing enzymes
Induction and inhibition of cytochromes P450 by the St. John's wort constituent hyperforin in human hepatocyte cultures.
- B. Komoroski, Shimin Zhang, R. Venkataramanan
- Biology, MedicineDrug metabolism and disposition: the biological…
- 1 May 2004
The results demonstrate that with chronic exposure, the inductive effect of SJW on drug-metabolizing enzymes predominates, and human hepatocyte cultures are a versatile in vitro tool for screening the effect of herbal products on cytochrome P450 enzymes.
ESRD impairs nonrenal clearance of fexofenadine but not midazolam.
- T. Nolin, R. Frye, J. Himmelfarb
- Biology, MedicineJournal of the American Society of Nephrology…
- 1 October 2009
Findings demonstrate a mechanism for altered drug disposition in kidney disease, which may partially account for the high rates of drug toxicity in this population of patients with ESRD and healthy control subjects.
Plasma levels of TNF-alpha and IL-6 are inversely related to cytochrome P450-dependent drug metabolism in patients with congestive heart failure.
- R. Frye, V. M. Schneider, C. Frye, A. Feldman
- Medicine, BiologyJournal of cardiac failure
- 1 October 2002
Cytokine-mediated decreases in drug metabolism may contribute to observed variability in drug response and augment the risk of adverse drug effects in CHF patients.
Cytochrome P450 mediated-drug metabolism is reduced in children with sepsis-induced multiple organ failure
YP 450 mediated drug metabolism is decreased in children with sepsis, related in part to the degree of inflammation and organ failure, and for drugs metabolized by CYP 450 enzymes there is an urgent need to reevaluate the use of standard drug dosage schedules in the sepsi population.
Effect of chronic disulfiram administration on the activities of CYP1A2, CYP2C19, CYP2D6, CYP2E1, and N-acetyltransferase in healthy human subjects.
The effects on caffeine N3-demethylation (CYP1A2) and dapsone metabolism suggest that chronic disulfiram administration may affect multiple drug metabolizing enzymes, which could potentially complicate the use of chronically administered disulfIRam as a diagnostic inhibitor of CYP2E1.
Evaluation of the Influence of Diabetes Mellitus on Antipyrine Metabolism and CYP1A2 and CYP2D6 Activity
Study Objective. To evaluate the metabolism of antipyrine, a general metabolic probe, caffeine, a probe for cytochrome P450 (CYP) 1A2 and N‐acetyltransferase activity, and dextromethorphan, a…
Tolbutamide, Flurbiprofen, and Losartan as Probes of CYP2C9 Activity in Humans
- Craig R. Lee, J. Pieper, A. Hinderliter, R. Frye, J. Blaisdell, J. Goldstein
- MedicineJournal of clinical pharmacology
- 1 January 2003
Tlbutamide is a better CYP2C9 probe than flurbiprofen and losartan, and the 0‐ to 12‐hour amount of 4'‐hydroxytolbutamide and carboxytol butamide is the best urinary measure of its metabolism.