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Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline.
TLDR
The guidelines for the evaluation and treatment of androgen deficiency syndromes in adult men published previously in 2006 are updated and testosterone therapy is recommended for men with symptomatic androgens deficiency to induce and maintain secondary sex characteristics.
Testosterone therapy in adult men with androgen deficiency syndromes: an endocrine society clinical practice guideline.
TLDR
The Task Force recommends testosterone therapy for symptomatic men with androgen deficiency, who have low testosterone levels, to induce and maintain secondary sex characteristics and to improve their sexual function, sense of well-being, muscle mass and strength, and bone mineral density.
The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men.
TLDR
Supraphysiologic doses of testosterone, especially when combined with strength training, increase fat-free mass and muscle size and strength in normal men.
Adverse events associated with testosterone replacement in middle-aged and older men: a meta-analysis of randomized, placebo-controlled trials.
TLDR
Testosterone replacement in older men was associated with a significantly higher risk of detection of prostate events and of hematocrit >50% than was placebo; he matocrit increase was the most frequent adverse event associated with testosterone replacement.
Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting.
TLDR
The hypothesis that myostatin is an attenuator of skeletal muscle growth in adult men and contributes to muscle wasting in HIV-infected men is supported.
Testosterone dose-response relationships in healthy young men.
TLDR
It is concluded that changes in circulating testosterone concentrations, induced by GnRH agonist and testosterone administration, are associated with testosterone dose- and concentration-dependent changes in fat-free mass, muscle size, strength and power, fat mass, hemoglobin, HDL cholesterol, and IGF-I levels, in conformity with a single linear dose-response relationship.
Adverse events associated with testosterone administration.
TLDR
In this population of older men with limitations in mobility and a high prevalence of chronic disease, the application of a testosterone gel was associated with an increased risk of cardiovascular adverse events.
Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline.
TLDR
It is suggested that when clinicians institute T therapy, they aim at achieving T concentrations in the mid-normal range during treatment with any of the approved formulations, taking into consideration patient preference, pharmacokinetics, formulation-specific adverse effects, treatment burden, and cost.
Clinical review 1: Adverse effects of testosterone therapy in adult men: a systematic review and meta-analysis.
TLDR
The adverse effects of testosterone therapy include an increase in hemoglobin and hematocrit and a small decrease in high-density lipoprotein cholesterol.
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