Evidence for Nontraditional Lymphatics in the Choroid.

@article{Alexander2015EvidenceFN,
  title={Evidence for Nontraditional Lymphatics in the Choroid.},
  author={Jonathan Steven Alexander and Felix Becker},
  journal={Investigative ophthalmology \& visual science},
  year={2015},
  volume={56 2},
  pages={
          1328
        },
  url={https://api.semanticscholar.org/CorpusID:10419036}
}
Interestingly lymphatic-like development was found to follow blood vessels, with both spreading outward from the optic nerve head, and could potentially represent a novel mechanism for regulating fluid homeostasis and immune functions in the choroid.
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Evaluation of the relationship of lymphangiogenesis markers with disease pathogenesis in patients with Behçet’s uveitis

LYVE-1 and PDPN can be good representatives of the ongoing inflammatory processes in BD uveitis and point out that the disease can be related to lymphangiogenesis.

4 References

Lymphatics and Lymphangiogenesis in the Eye

A better understanding of lymphatic and lymphangiogenesis in the eye will open new therapeutic opportunities to prevent vision loss in ocular diseases, especially inflammatory disease or edema.

Evidence for lymphatics in the developing and adult human choroid.

The presence of a system of lymphatic-like channels in the human choroid provides an anatomical basis for antigen presentation in the posterior eye, with a possible route from the eye to the sentinel lymph nodes, similar to that already described for anterior eye lymphatics.

Expression of podoplanin and other lymphatic markers in the human anterior eye segment.

Coexpression of Pdpn and Ccl21 at the anterior iris surface and in the chamber angle suggests the constitution of a chemokine gradient guiding APCs through the anterior chamber.

The normal human choroid is endowed with a significant number of lymphatic vessel endothelial hyaluronate receptor 1 (LYVE-1)-positive macrophages.

The normal adult human choroid does not contain typical lymph vessels, but is endowed with a significant number of LYVE-1 positive macrophages, which may be involved in choroidal hyaluronic acid metabolism or contribute to temporary formation of lymphatic channels under inflammatory conditions.