• Publications
  • Influence
The critical role of ocular‐infiltrating macrophages in the development of choroidal neovascularization
Choroidal neovascularization (CNV) is directly related to visual loss in some eye diseases, such as age‐related macular degeneration. Although several human histological studies have suggested theExpand
  • 226
  • 16
Monocyte chemoattractant protein 1 mediates retinal detachment-induced photoreceptor apoptosis
Photoreceptor apoptosis is a major cause of visual loss in retinal detachment (RD) and several other visual disorders, but the underlying mechanisms remain elusive. Recently, increased expression ofExpand
  • 229
  • 15
  • PDF
Infiltration of COX-2-expressing macrophages is a prerequisite for IL-1 beta-induced neovascularization and tumor growth.
Inflammatory angiogenesis is a critical process in tumor progression and other diseases. The inflammatory cytokine IL-1beta promotes angiogenesis, tumor growth, and metastasis, but its mechanismsExpand
  • 244
  • 9
  • PDF
Cyclooxygenase 2 is a key enzyme for inflammatory cytokine‐induced angiogenesis
  • T. Kuwano, S. Nakao, +4 authors M. Ono
  • Medicine, Biology
  • FASEB journal : official publication of the…
  • 1 February 2004
Cyclooxygenasel (COX1) and COX2 mediate the rate‐limiting step in arachidonic acid me¬tabolism. Expression of COX2 mRNA and protein is often enhanced in various human cell types by inflam¬matoryExpand
  • 241
  • 8
Delayed neutrophil elastase inhibition prevents subsequent progression of acute lung injury induced by endotoxin inhalation in hamsters.
To define the role of neutrophil elastase (NE) in the progression of acute lung injury (ALI), we examined the effects of post-treatment with a specific NE inhibitor, sivelestat sodium hydrateExpand
  • 159
  • 8
  • PDF
Role of macrophages in inflammatory lymphangiogenesis: Enhanced production of vascular endothelial growth factor C and D through NF-kappaB activation.
The close association of inflammation, angiogenesis and cancer progression is now highlighted, and in this study we especially focused on a close association of inflammation and lymphangiogenesis. WeExpand
  • 92
  • 8
Leukocyte Adhesion Molecules in Diabetic Retinopathy
Diabetes is a systemic disease that causes a number of metabolic and physiologic abnormalities. One of the major microvascular complications of diabetes is diabetic retinopathy (DR), a leading causeExpand
  • 64
  • 6
  • PDF