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Seven New Loci Associated with Age-Related Macular Degeneration
Age-related macular degeneration (AMD) is a common cause of blindness in older individuals. To accelerate the understanding of AMD biology and help design new therapies, we executed a collaborativeExpand
Involvement of interleukin-8, vascular endothelial growth factor, and basic fibroblast growth factor in tumor necrosis factor alpha-dependent angiogenesis.
Tumor necrosis factor alpha (TNF-alpha) is a macrophage/monocyte-derived polypeptide which modulates the expression of various genes in vascular endothelial cells and induces angiogenesis. However,Expand
Comprehensive Analysis of Inflammatory Immune Mediators in Vitreoretinal Diseases
Inflammation affects the formation and the progression of various vitreoretinal diseases. We performed a comprehensive analysis of inflammatory immune mediators in the vitreous fluids from total ofExpand
The critical role of ocular‐infiltrating macrophages in the development of choroidal neovascularization
Choroidal neovascularization (CNV) is directly related to visual loss in some eye diseases, such as age‐related macular degeneration. Although several human histological studies have suggested theExpand
Cutting Edge: Role of IL-27/WSX-1 Signaling for Induction of T-Bet Through Activation of STAT1 During Initial Th1 Commitment1
WSX-1 is a member of the class I cytokine receptor family with homology to IL-12Rβ2 and is essential for the initial mounting of Th1 responses. STAT1 interacts with tyrosine-phosphorylated WSX-1, andExpand
CCR3 is a target for age-related macular degeneration diagnosis and therapy
Age-related macular degeneration (AMD), a leading cause of blindness worldwide, is as prevalent as cancer in industrialized nations. Most blindness in AMD results from invasion of the retina byExpand
Expression of vascular endothelial growth factor in experimental choroidal neovascularization
Abstract• Background: Although the choroidal neovascularization (CNV) is a common pathologic feature of a number of different eye diseases, its pathological mechanisms have not been fully elucidated.Expand
International photographic classification and grading system for myopic maculopathy.
PURPOSE To develop a classification and grading system for myopic maculopathy. DESIGN Development and evaluation of a classification system for myopic maculopathy based on observational caseExpand
Purpose: To report the use of the dye brilliant blue G (BBG) for staining of the internal limiting membrane (ILM) during macular hole (MH) and epiretinal membrane (ERM) surgery. Methods: This studyExpand
Prevalence of age related maculopathy in a representative Japanese population: the Hisayama study
AIM To determine the prevalence of age related maculopathy (ARM) in a representative older Japanese population. METHODS 1486 residents of Hisayama town, Fukuoka, Japan, aged 50 years or older wereExpand