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The MT domain of the proto-oncoprotein MLL binds to CpG-containing DNA and discriminates against methylation.
TLDR
It is demonstrated that this domain specifically recognizes DNA with unmethylated CpG sequences, and was corroborated in vivo in reporter assays utilizing the DNA-binding properties of the MT domain in a hybrid MT-VP16 transactivator construct. Expand
Transforming growth factor-beta 2 modulated extracellular matrix component expression in cultured human optic nerve head astrocytes.
TLDR
TGF-beta 2 is capable of inducing the expression of ECM and basement membrane components in cultured ONH astrocytes via CTGF and upregulated TSP-1, a protein naturally involved in the activation of latent TGF- beta. Expand
Expression of podoplanin and other lymphatic markers in the human anterior eye segment.
TLDR
Coexpression of Pdpn and Ccl21 at the anterior iris surface and in the chamber angle suggests the constitution of a chemokine gradient guiding APCs through the anterior chamber. Expand
The effect of TGF-beta2 on elastin, type VI collagen, and components of the proteolytic degradation system in human optic nerve astrocytes.
TLDR
TGF-beta2 induces expression of elastin and ColVI and thereby could contribute to the increase of type VI collagen fibers in the tissue septae and the elastotic changes typically observed in POAG. Expand
The ENL moiety of the childhood leukemia-associated MLL–ENL oncoprotein recruits human Polycomb 3
TLDR
The recruitment of a repressive function by ENL opens up a new insight into a possible mechanism of leukemogenesis by the fusion protein MLL–ENL. Expand
ENL, the MLL fusion partner in t(11;19), binds to the c-Abl interactor protein 1 (ABI1) that is fused to MLL in t(10;11)+
TLDR
It is shown here that the frequent MLL fusion partner ENL at 19p13.1 interacts with the human homologue of the mouse Abl-Interactor 1 (ABI1) protein, which is fused to MLL in the t(10;11)(p11.2;q23) translocation. Expand
AAV-mediated expression of human PRELP inhibits complement activation, choroidal neovascularization and deposition of membrane attack complex in mice
TLDR
The potential of human proline/arginine- rich end leucine-rich repeat protein (PRELP) as an inhibitor of complement-mediated damage when delivered via the subretinal route using an AAV2/8 vector is investigated and implications for the development of complement inhibitors as a therapy for AMD are investigated. Expand
Preventive Effects of Omega-3 and Omega-6 Fatty Acids on Peroxide Mediated Oxidative Stress Responses in Primary Human Trabecular Meshwork Cells
TLDR
Based on the observed side effects of omega-6, omega-3 appears to be the more beneficial fatty acid in respect of prophylactic intake for prevention of a glaucomatous disease. Expand
Hypoxia/reoxygenation and TGF-beta increase alphaB-crystallin expression in human optic nerve head astrocytes.
TLDR
The process of hypoxia/reoxygenation is capable of inducing the expression of alphaB-crystallin and TGF-ss in cultured ONH astrocytes and optimization of conditions leading to hypoxianization in the ONH of glaucomatous patients may lower the incidence of characteristic changes in the optic nerve. Expand
Ultrastructural and biochemical evaluation of the porcine anterior chamber perfusion model.
TLDR
These new ultrastructural investigations indicate that the cribriform and subendothelial regions of the porcine TM have an architecture similar to that of the primate TM. Expand
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