Dimethoxycurcumin, a synthetic curcumin analogue with higher metabolic stability, inhibits NO production, inducible NO synthase expression and NF-kappaB activation in RAW264.7 macrophages activated with LPS.

@article{Pae2008DimethoxycurcuminAS,
  title={Dimethoxycurcumin, a synthetic curcumin analogue with higher metabolic stability, inhibits NO production, inducible NO synthase expression and NF-kappaB activation in RAW264.7 macrophages activated with LPS.},
  author={Hyun Ock Pae and Sun-oh Jeong and Hak Sung Kim and Seong Heak Kim and Yung-sun Song and Sung-kwun Kim and Kyu Yun Chai and Hun-taeg Chung},
  journal={Molecular nutrition \& food research},
  year={2008},
  volume={52 9},
  pages={
          1082-91
        },
  url={https://api.semanticscholar.org/CorpusID:25260202}
}
The results suggest that DiMC inhibits NO production, iNOS expression and NF-kappaB activation in LPS-activated macrophages, which may be due not only to the conjugated double bonds but also the increased number of methoxy groups.
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49 Citations

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25 References

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Capsazepine, a vanilloid receptor antagonist, inhibits the expression of inducible nitric oxide synthase gene in lipopolysaccharide-stimulated RAW264.7 macrophages through the inactivation of nuclear transcription factor-kappa B.

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Nitric oxide as a bioregulator of apoptosis.

The antiapoptotic mechanism can be understood via expression of protective genes such as heat shock proteins, Bcl-2 as well as direct inhibition of the apoptotic caspase family proteases by S-nitrosylation of the cysteine thiol.

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Evidence has also been presented to suggest that curcumin can suppress tumor initiation, promotion and metastasis, and Pharmacologically,Curcumin has been found to be safe.