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Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the
TLDR
Zerumbone is a food phytochemical that has distinct potentials for use in anti-inflammation, chemoprevention, and chemotherapy strategies, and alpha-humulene, a structural analog lacking only the carbonyl group in ZER, was virtually inactive in all experiments conducted, indicating that the alpha,beta-unsaturated carbony l group may play some pivotal roles in interactions with unidentified target molecule(s).
The CED-4-homologous protein FLASH is involved in Fas-mediated activation of caspase-8 during apoptosis
TLDR
A large new protein, FLASH, has been identified by cloning of its complementary DNA and contains a motif with oligomerizing activity whose sequence is similar to that of the Caenorhabditis elegans protein CED-4, and another domain (DRD domain) that interacts with a death-effector domain in caspase-8 or in the adapter protein.
Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism.
TLDR
It is demonstrated that different analogs of curcumin present in turmeric exhibit variable anti-inflammatory and anti-proliferative activities, which do not correlate with their ability to modulate the ROS status.
Ursolic acid: an anti- and pro-inflammatory triterpenoid.
TLDR
Ursolic acid (UA), a natural pentacyclic triterpenoid carboxylic acid, is the major component of some traditional medicine herbs and is well known to possess a wide range of biological functions that are able to counteract endogenous and exogenous biological stimuli.
Targeting NOX, INOS and COX‐2 in inflammatory cells: Chemoprevention using food phytochemicals
TLDR
The cancer preventive potentials of several food phytochemicals targeting the induction of NOX, iNOS and COX‐2 are described.
Sphingosine 1-Phosphate (S1P) Regulates Vascular Contraction via S1P3 Receptor: Investigation Based on a New S1P3 Receptor Antagonist
TLDR
The results clearly show that TY-52156 is both sensitive and useful as an S1P3 receptor-specific antagonist and reveal that S 1P induces vasoconstriction by directly activating S1p3 receptor and through a subsequent increase in [Ca2+]i and Rho activation in vascular smooth muscle cells.
Dietary rutin, but not its aglycone quercetin, ameliorates dextran sulfate sodium-induced experimental colitis in mice: attenuation of pro-inflammatory gene expression.
TLDR
Dietary rutin ameliorates DSS-induced colitis, presumably by suppressing the induction of pro-inflammatory cytokines, and may be useful for the prevention and treatment of IBD and colorectal carcinogenesis.
Multitargeted cancer prevention by quercetin.
TLDR
Dietary quercetin is a promising agent for cancer prevention and further research is warranted, as it prevents chemically induced carcinogenesis and modulates several signal transduction pathways involving MEK/ERK and Nrf2/keap1.
Redox regulation of glutathione S-transferase induction by benzyl isothiocyanate: correlation of enzyme induction with the formation of reactive oxygen intermediates.
TLDR
The involvement of the redox regulation on the induction of GSTP1 by BITC is suggested, as well as the structure-activity relationship of the isothiocyanates, which indicated that the ROI-producing activities closely correlated with their GST-inducing potencies.
Zerumbone abolishes NF-κB and IκBα kinase activation leading to suppression of antiapoptotic and metastatic gene expression, upregulation of apoptosis, and downregulation of invasion
TLDR
It is found that zerumbone suppressed NF-κB activation induced by tumor necrosis factor (TNF), okadaic acid, cigarette smoke condensate, phorbol myristate acetate, and H2O2 and that the suppression was not cell type specific.
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