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Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL.
- H. Yasuda, N. Shima, +13 authors T. Suda
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 31 March 1998
Osteoclasts, the multinucleated cells that resorb bone, develop from hematopoietic cells of monocyte/macrophage lineage. Osteoclast-like cells (OCLs) are formed by coculturing spleen cells with… Expand
Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro.
The morphogenesis and remodeling of bone depends on the integrated activity of osteoblasts that form bone and osteoclasts that resorb bone. We previously reported the isolation of a new cytokine… Expand
Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the…
Zerumbone (ZER), a sesquiterpene from the edible plant Zingiber zerumbet Smith, has recently been found to suppress tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced Epstein-Barr… Expand
Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism.
Curcumin, a component of turmeric (Curcuma longa), has been shown to exhibit chemopreventive activity. Whether analogs of curcumin (Cur), such as demethoxycurcumin (DMC), bisdemethoxycurcumin (BDMC),… Expand
Targeting NOX, INOS and COX‐2 in inflammatory cells: Chemoprevention using food phytochemicals
Biological, biochemical and physical stimuli activate inflammatory leukocytes, such as macrophages, resulting in induction and synthesis of proinflammatory proteins and enzymes, together with free… Expand
The CED-4-homologous protein FLASH is involved in Fas-mediated activation of caspase-8 during apoptosis
- Y. Imai, T. Kimura, A. Murakami, N. Yajima, K. Sakamaki, S. Yonehara
- Biology, Medicine
- 29 April 1999
Fas is a cell-surface receptor molecule that relays apoptotic (cell death) signals into cells. When Fas is activated by binding of its ligand, the proteolytic protein caspase-8 is recruited to a… Expand
Ursolic acid: an anti- and pro-inflammatory triterpenoid.
There is growing interest in the elucidation of the biological functions of triterpenoids, ubiquitously distributed throughout the plant kingdom, some of which are used as anticancer and… Expand
Dietary rutin, but not its aglycone quercetin, ameliorates dextran sulfate sodium-induced experimental colitis in mice: attenuation of pro-inflammatory gene expression.
- K. Kwon, A. Murakami, T. Tanaka, H. Ohigashi
- Chemistry, Medicine
- Biochemical pharmacology
- 1 February 2005
Oxidative stress has been shown to play a pivotal role in the onset of inflammatory bowel disease (IBD) and carcinogenesis. We evaluated the effects of two dietary anti-oxidants, rutin and its… Expand
Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerin.
- A. Mizuno, N. Amizuka, +15 authors H. Ozawa
- Biology, Medicine
- Biochemical and biophysical research…
- 29 June 1998
Osteoclasts are multinucleated cells that resorb bone. Osteoclastogenesis inhibitory factor (OCIF), also called osteoprotegerin (OPG), acts as a naturally occurring decoy receptor for osteoclast… Expand
Multitargeted cancer prevention by quercetin.
Quercetin is an anti-oxidative flavonoid widely distributed in the plant kingdom. Phenolic hydroxyl groups at the B-ring and the 3-position are responsible for its free radical-scavenging activity.… Expand